All About Histamine H3 Receptors (HRH3/HR3): Genetics, Mechanisms, And Antagonists

Is histamine a villain… or really a superhero?

It really depends on which receptor it works on and where it is in the body.

In this post, we will discuss how to use the 3rd histamine receptor to boost cognition, memory, and attention.

We will first discuss how the histamine receptors work.

Then, we will move onto the benefits (and downsides) of blocking Histamine H3 Receptor's (HRH3 or H3R) activity with natural and pharmacological methods.

Lastly, we will discuss the potential benefits of increasing HRH3 with some agonists, HRH3's mechanism of action, and some important HRH3 SNPs.

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HOMER1, HOMER2, and HOMER3: How These Homologs Promote Strong Synaptic Plasticity

In this post, we will discuss Homer proteins (mainly homer1), their implicated diseases with dysregulation, and some novel ways to help with homeostasis.

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The Role of DARPP-32 In Addiction, Schizophrenia & Parkinson's Disease

In this post, we will discuss how protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) plays a large role addiction, Parkinson's Disease, schizophrenia, cognition, and cancer. 

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256+ Ways To Increase Dopamine Naturally (Supplements And Genetics)

Dopamine is extremely important for everyday function and plays a much larger role in the body than just bonding, motivation, cognition, emotion, well-being, and movement.

Unfortunately, our environment today is very good at manipulating and hijacking our dopamine system.

In this post we will discuss, how/why dopamine is produced, how chronic inflammation affects dopamine, what are some quick fixes for dopamine, and what are some long lasting dopamine builders, as well how to avoid losing dopamine. 

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The 5+ Benefits Of KB220, KB220Z, and Neuroadaptagen Amino-Acid Therapy

There are many ways to improve dopamine levels in the brain - dopamine-enhancing diets, hyper-oxygenation, toxic heavy metal detoxification, exercise, meditation, yoga, but most notably, balancing brain neurotransmitters utilizing nutraceuticals aka "neuronutrients". 

KB220z (aka KB220 and formerly known as LG9939, Recomposize, Genotrim) is a "neuronutrient" that acts on optimizing glutamatedopamineserotonin, and endorphins in the brain. 

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The 21+ Benefits Of Beta-Caryophyllene (The Common Cannabinoid)

Beta-Caryophyllene Is A Very Common Cannabinoid

β-caryophyllene is a FDA-approved food additive that can activate the endocannabinoid system. 

It is found in many plants, fragerances, preservatives, additives, and flavoring agents.

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The 10+ Benefits of Thunbergia Laurifolia (Laurel Clockvine)

Thunbergia Laurifolia is a traditional herb in Thailand that has a variety potential benefits. 

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Balancing Excitatory Amino Acid Transporter Activity

Controlling Excitatory Amino Acid Transporters (EAATs) activity is a novel way to reduce excitotoxicity (neuronal damage due to overactivity) in the brain

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The 10+ Benefits of Beta-Lactam Antibiotics And Ceftriaxone

I usually advise to stay away from all antibiotics, but I've had clients that have had profoundly beneficial experiences with certain beta-lactam antibiotics

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The 10+ Benefits of Liraglutide

Liraglutide protects the brain, improve weight loss, and protect against many of the problems associated with metabolic syndromes.

A lot of its effects with diabetes, obesity and the brain are based on liraglutide's ability to change the composition of the gut microbiome.

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The 15+ Benefits of Broccoli Sprouts And Sulforaphane (And How To Prepare Them)

Sulforaphane (SFN) is naturally occurring in broccoli sprouts, which has the highest amount of sulforaphane.

Broccoli sprouts contain a particular glucosinolate compound, glucoraphanin, which is found in vacuoles within the cytoplasm of the plant cell. 

The membrane of the plant cells also contain an enzyme, myrosinase, which is walled off from the vacuoles of glucoraphanin. 

Only when the plant cell is ruptured by cutting/chewing,. do the two substances come into contact with each other. 

In the moist environment of the cell, this leads to a chemical reaction wherein the myrosinase converts the glucoraphanin to an isothiocyanate, sulforaphane. 

It is also found in cruciferous veggies, such as brussels spout, cabbage, cauliflower, bok choy, kale, collards, Chinese broccoli, broccoli raab, kohlrabi, mustard, turnip, radish, arugula, and watercress. 

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Why I Don't Drink Alcohol (The Social, Moral and Health Benefits of Not Drinking)

Ever since I gave up alcohol, I very rarely get sick, my sleep has improved drastically, my mental health is much more stable, I have MUCH more confidence in myself, I am more accepting of others, my social skills have improved in EVERY aspect, and I get "drunk" in much better ways.

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The 49+ Benefits of THC, CBD, and The Endocannabinoid System

Medical marijuana and legalization have been a hot topics recently. I wanted to cover the plethora of benefits of the endocannabinoid system.

Disclaimer: I made sure to only work on this post while vaping CBD.

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GDNF: What It Is and 67+ Natural Ways To Increase Glial Cell Line-Derived Neurotrophic Factor

Glial cell line-derived neurotrophic factor (GDNF) is an essential growth factor for the kidneys, spinal cord, exerting a wide range of effects on addiction, Alzheimer's, Parkinson's, neuropathy, gut inflammation, and more. 

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