Mast Cells (Part 3): The Mast Cell-Glia Interaction In Chronic Inflammation

In this post we will focus on the mast cell-glia (microglia, astrocyte, oligodendrocyte) interaction with our body and how they contribute to chronic inflammatory diseases such as CIRS and SALI.

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The 16+ Benefits Of Catuaba (Trichilia Catigua And Other Catuabas)

Catuaba is a powerful plant that can improve depression, anxiety, fatigue, and more.

In this post, we will discuss the different forms of Catuaba (true vs non-true catuabas), the benefits of catuaba, and dosage of catuaba.

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What Is Toxin Bioaccumulation? How Biotoxin Accumulation Causes (Reversible) Chronic Dysfunction

Recent evidence suggests that 70–90% of chronic disease is likely related to environmental determinants. 

In this post, we will discuss how biotoxin accumulation may cause chronic illness.

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HOMER1, HOMER2, and HOMER3: How These Homologs Promote Strong Synaptic Plasticity

In this post, we will discuss Homer proteins (mainly homer1), their implicated diseases with dysregulation, and some novel ways to help with homeostasis.

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PON1: Increase Longevity And Detox Pesticides with 99+ Ways To Increase Paraoxonase 1

Paraoxonase 1 (PON1) is an enzyme that plays a role in most diseases.

In this post, we will discuss how you can use PON1 to improve overall health, longevity, and detox mechanisms.  

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Humanin: 7+ Ways To Increase Mitochondria's IGF-1

The term Humanin (HN) was coined by its discoverer, Professor Nishimoto, to denote the potential of this molecule to restore the “humanity” of patients with Alzheimer’s disease. 

Later we have found humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults as well as also improves cardiovascular disease and Alzheimer's disease. 

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DJ-1/PARK7: How To Revive NRF2 (with 27+ Ways To Increase Protein Deglycase DJ-1)

Protein deglycase DJ-1 (DJ-1), also known as Parkinson disease protein 7 (PARK7) is a master regulator of redox status.

In this post, we will discuss how DJ-1 increases dopamine, enhances mitochondria, and combats most oxidative-stress related diseases. 

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How To Inhibit Lipopolysaccharides (LPS), Lipoglycans, and Endotoxins

Recent data suggests that chronically low levels of circulating LPS may be associated with the development of metabolic diseases such as insulin resistance, type 2 diabetes, atherosclerosis and cardiovascular disease. R

In this post, we will discuss how LPS affects the body and how to reverse endotoxemia.

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256+ Ways To Increase Dopamine Naturally (Supplements And Genetics)

Dopamine is extremely important for everyday function and plays a much larger role in the body than just bonding, motivation, cognition, emotion, well-being, and movement.

Unfortunately, our environment today is very good at manipulating and hijacking our dopamine system.

In this post we will discuss, how/why dopamine is produced, how chronic inflammation affects dopamine, what are some quick fixes for dopamine, and what are some long lasting dopamine builders, as well how to avoid losing dopamine. 

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Why NRF2 Activation Can Make You More Sick

Recent cancer research has helped us understand how the body detoxes.

By studying upregulated genes in tumorous cells, we were able to find the Nuclear Erythroid 2–Related Factor 2 (NRF2) pathway.

NRF2 is a major transcription factor in detoxing the body and keeping it healthy.

In this post, we will discuss the benefits/downsides of NRF2 activation, as well as why NRF2 may be hurting you more than helping you (and what you can do about it).

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Balancing Excitatory Amino Acid Transporter Activity

Controlling Excitatory Amino Acid Transporters (EAATs) activity is a novel way to reduce excitotoxicity (neuronal damage due to overactivity) in the brain

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The 10+ Benefits of Beta-Lactam Antibiotics And Ceftriaxone

I usually advise to stay away from all antibiotics, but I've had clients that have had profoundly beneficial experiences with certain beta-lactam antibiotics

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Glyphosate & Roundup Inhibit Vitamin D and Cause Nutritional Deficiencies

Since the late 1970s, the use of glyphosate-based herbicides (GBHs) has increased approximately 100-fold. 

Glyphosate is the active ingredient in Roundup®. 

In this post, we will discuss glyphosate's toxic effects (even at extremely low doses). 

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Inhibiting Nogo-A For Increased Brain Plasticity

Nogo-A is one of the most potent growth inhibitors in the central nervous system.

It is involved in creating new blood cells, developing new stem cells, protecting growth of cancer, and modulating the immune system.

It is highly expressed after adolescent development, traumatic brain injuries, and many myelin-related diseases.

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IL-8: 53 Ways to Naturally And Artificially Lower This Chemokine

Interleukin 8 (IL8 or CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. 

IL-8, also known as neutrophil chemotactic factor, has two primary functions: 

It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection.
It also induces phagocytosis once they have arrived.

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The 49+ Benefits of THC, CBD, and The Endocannabinoid System

Medical marijuana and legalization have been a hot topics recently. I wanted to cover the plethora of benefits of the endocannabinoid system.

Disclaimer: I made sure to only work on this post while vaping CBD.

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CNTF: Its Role in The Body And How To Increase Ciliary Neurotrophic Factor

Ciliary neurotrophic factor (CNTF) is a neurotrophic factor with promising benefits in a wide range of pathologies such asneurodegenerative diseases, spinal cord injuries, retinal degeneration, autoimmune neuroinflammation and obesity-related metabolic diseases.

 

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