How Ciguatoxins Cause CIRS, Brain Fog, & Loss of NAD+

Ciguatoxins are a harmful byproduct of marine life and their exposure can cause both acute and chronic long term neurological effects.

In this post, we will discuss how ciguatoxins can cause CIRS, brain fog, and loss of NAD+.

Read More

The 27+ Benefits Of Ecklonia Cava and Phlorotannins

Ecklonia cava is a powerful brown algae that shows promising potential in many metabolic diseases.

In this post, we will discuss the benefits of Ecklonia cava, where to buy it, and its mechanism of action.

Read More

All About Phoenixin: Pros And Cons Of Phoenixin And GPR173

Phoenixin is a peptide that regulates reproductive function, behavior, sensory perception, memory retention, cardiovascular health and food intake.

Read More

The 19+ Benefits Of Zeolite And Clinoptilolites

Zeolites are very promising for improving environment protection, detoxication, human nutrition status and immunity, separation of various biomolecules and cells, construction of biosensors and detection of biomarkers of various diseases, proper drug/gene delivery, antioxidant regulation, and tissue engineering.

In this post, we will discuss where zeolites come from, its benefits/downsides, and where to get zeolite.

Read More

Do You Have Systemic And Long-term Inflammation? (SALI)

Do you have CIRS that does not go away with the traditional or manipulated versions of the protocol?

In this post, we will discuss what is SALI and how this may be a better way to look at similar chronic diseases.

Read More

The 14+ Benefits of PeaLut / Glialia (Palmitoylethanolamide + Luteolin)

PeaLut is the combination of two powerful components that when combined can abolish inflammation, increase hippocampal growth, and reduce pain.

In this post, we will discuss the benefits of PeaLut and where to buy it.

Read More

The 27+ Benefits Of Matrine (with Natural Sources And Mechanisms)

Matrine is a very powerful alkaloid that has many neuropharmalogical benefits.

In this post, we will discuss matrine's benefits, natural sources for it, and some of matrine's 195+ mechanisms.

Read More

The 8+ Benefits Of Sophoraflavanone G (with Mechanisms and Natural Sources)

Sophoraflavanone G (SG) is a flavonoid and phytoncide with powerful effects on quenching inflammation and fighting microbes.

Read More

The 6+ Benefits Of Sophoflavescenol (With Natural Sources And Mechanisms)

In this post, we will discuss natural sources of sophoflavescenol and its benefits.

Read More

How GPR84 Senses And Potentiates Inflammation

GPR84 is an inflammation sensor that plays a role in endotoxemia, brain injuries, and obesity.

In this post, we will discuss how to regulate GPR84's function. 

Read More

What Is Toxin Bioaccumulation? How Biotoxin Accumulation Causes (Reversible) Chronic Dysfunction

Recent evidence suggests that 70–90% of chronic disease is likely related to environmental determinants. 

In this post, we will discuss how biotoxin accumulation may cause chronic illness.

Read More

The 7+ Benefits Of Suvorexant (Belsomra): A Dual Orexin Receptor Antagonist

Suvorexant is a dual-orexin receptor antagonist that improves insomnia.

Read More

All About Histamine H3 Receptors (HRH3/HR3): Genetics, Mechanisms, And Antagonists

Is histamine a villain… or really a superhero?

It really depends on which receptor it works on and where it is in the body.

In this post, we will discuss how to use the 3rd histamine receptor to boost cognition, memory, and attention.

We will first discuss how the histamine receptors work.

Then, we will move onto the benefits (and downsides) of blocking Histamine H3 Receptor's (HRH3 or H3R) activity with natural and pharmacological methods.

Lastly, we will discuss the potential benefits of increasing HRH3 with some agonists, HRH3's mechanism of action, and some important HRH3 SNPs.

Read More

The 8+ Benefits Of J147: A Potent Curcumin Derivative (And How To Make T-006)

Unlike the current drugs approved for Alzheimer's Disease, J147 is neither an acetylcholinesterase inhibitor nor a phosphodiesterase inhibitor, yet it enhances cognition with a short-term treatment.

In this post, we will discuss how the curcumin derivative J147 improves memory and I'll explain a very powerful alternative way to get its benefits.

Read More

Are You ApoE4? 88+ Ways To Increase Apolipoprotein E (ApoE)

ApoE is a master regulator for many genes implicated in cholesterol metabolism (such as Alzheimer's Disease and Atherosclerosis).

In this post, we will discuss the benefits and downsides of ApoE, how to determine if you are ApoE2, E3, or E4, and ways to fix it.

Read More

Humanin: 7+ Ways To Increase Mitochondria's IGF-1

The term Humanin (HN) was coined by its discoverer, Professor Nishimoto, to denote the potential of this molecule to restore the “humanity” of patients with Alzheimer’s disease. 

Later we have found humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults as well as also improves cardiovascular disease and Alzheimer's disease. 

Read More

DJ-1/PARK7: How To Revive NRF2 (with 27+ Ways To Increase Protein Deglycase DJ-1)

Protein deglycase DJ-1 (DJ-1), also known as Parkinson disease protein 7 (PARK7) is a master regulator of redox status.

In this post, we will discuss how DJ-1 increases dopamine, enhances mitochondria, and combats most oxidative-stress related diseases. 

Read More

How To Inhibit Lipopolysaccharides (LPS), Lipoglycans, and Endotoxins

Recent data suggests that chronically low levels of circulating LPS may be associated with the development of metabolic diseases such as insulin resistance, type 2 diabetes, atherosclerosis and cardiovascular disease. R

In this post, we will discuss how LPS affects the body and how to reverse endotoxemia.

Read More

The 27+ Benefits Of Burdock (Arctium lappa)

Burdock root has been used for centuries (over 3000 years) in China and in traditional Chinese medicine (TCM) for "purifying the blood", but in this post we will discuss the actual ways burdock works on improving the body.

Read More

256+ Ways To Increase Dopamine Naturally (Supplements And Genetics)

Dopamine is extremely important for everyday function and plays a much larger role in the body than just bonding, motivation, cognition, emotion, well-being, and movement.

Unfortunately, our environment today is very good at manipulating and hijacking our dopamine system.

In this post we will discuss, how/why dopamine is produced, how chronic inflammation affects dopamine, what are some quick fixes for dopamine, and what are some long lasting dopamine builders, as well how to avoid losing dopamine. 

Read More