X-Linked Inhibitor Of Apoptosis (XIAP) And How To Inhibit XIAP

X-Linked Inhibitor Of Apoptosis (XIAP) has shown to play a role in cancer, longevity, inflammatory resistance, and more.

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The 8+ Benefits Of J147: A Potent Curcumin Derivative (And How To Make T-006)

Unlike the current drugs approved for Alzheimer's Disease, J147 is neither an acetylcholinesterase inhibitor nor a phosphodiesterase inhibitor, yet it enhances cognition with a short-term treatment.

In this post, we will discuss how the curcumin derivative J147 improves memory and I'll explain a very powerful alternative way to get its benefits.

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DJ-1/PARK7: How To Revive NRF2 (with 27+ Ways To Increase Protein Deglycase DJ-1)

Protein deglycase DJ-1 (DJ-1), also known as Parkinson disease protein 7 (PARK7) is a master regulator of redox status.

In this post, we will discuss how DJ-1 increases dopamine, enhances mitochondria, and combats most oxidative-stress related diseases. 

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How To Have Your Cake And Eat It Too: Calorie Restriction And Fasting Mimetics

Calorie Restriction Mimetics (CRMs) are compounds that can induce the same mechanisms as eating less, without having to actually eat less. 

In this post, we will discuss how to have your cake (food) and eat it too. 

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The Role of DARPP-32 In Addiction, Schizophrenia & Parkinson's Disease

In this post, we will discuss how protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) plays a large role addiction, Parkinson's Disease, schizophrenia, cognition, and cancer. 

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The 27+ Benefits Of Burdock (Arctium lappa)

Burdock root has been used for centuries (over 3000 years) in China and in traditional Chinese medicine (TCM) for "purifying the blood", but in this post we will discuss the actual ways burdock works on improving the body.

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256+ Ways To Increase Dopamine Naturally (Supplements And Genetics)

Dopamine is extremely important for everyday function and plays a much larger role in the body than just bonding, motivation, cognition, emotion, well-being, and movement.

Unfortunately, our environment today is very good at manipulating and hijacking our dopamine system.

In this post we will discuss, how/why dopamine is produced, how chronic inflammation affects dopamine, what are some quick fixes for dopamine, and what are some long lasting dopamine builders, as well how to avoid losing dopamine. 

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How To Stop Protein Misfolding (Proteopathy)

I tried folding protein once, but all I got was a ham and cheese sandwich.

In this post we're discussing proteopathy, how proteins can cause chronic disease, and some strategies to prevent it all. 

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How Cadmium Damages Mitochondria And What To Do About It

In western society, cadmium (Cd) is found in our everyday environment.

It causes toxic effects to the whole body, including the cells and mitochondria.

In this post, we will discuss how cadmium affects the body and what you can do to protect yourself.

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Why NRF2 Activation Can Make You More Sick

Recent cancer research has helped us understand how the body detoxes.

By studying upregulated genes in tumorous cells, we were able to find the Nuclear Erythroid 2–Related Factor 2 (NRF2) pathway.

NRF2 is a major transcription factor in detoxing the body and keeping it healthy.

In this post, we will discuss the benefits/downsides of NRF2 activation, as well as why NRF2 may be hurting you more than helping you (and what you can do about it).

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The 21+ Benefits Of Beta-Caryophyllene (The Common Cannabinoid)

Beta-Caryophyllene Is A Very Common Cannabinoid

β-caryophyllene is a FDA-approved food additive that can activate the endocannabinoid system. 

It is found in many plants, fragerances, preservatives, additives, and flavoring agents.

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380+ Ways To Inhibit Biofilms

Biofilms (sometimes described as "cities for microbes") are glue-like membranes produced by microbes (bacteria, fungi and yeasts) to protect themselves being discovered by our immune system, among other functions (described below). 

In this post, we're going to go over what diet and supplements (as well as advanced techniques) can be used to prevent and/or kill unwanted biofilms from common bacterial and fungal pathogens.

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How Chronic Fluoride Can Damage Mitochondria And The Gut Biome

Fluoride is a trace element, but it is found in our daily exposure more than a "trace". 

In small amounts, it appears to be okay

The problems with fluoride appear to be in chronic use of it over long periods of time, and/or being exposed to a high dose of it in a single instance. 

Apart from skeletal tissue and teeth, fluoride can cause changes in the kidneys, liver, thyroid, parathyroid, pituitary gland, testis, muscle tissues, stomach, brain, neurons, and immune system. 

I have mild dental fluorosis, probably from drinking too much fluoridated water, using fluoridated toothpaste, along with taking fluoride at the dentist to protect my enamel. 

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The Sun Diet (Food as Sunscreen)

We need the sun for many biological processes.

The sun produces ultraviolet (UV) radiation.

UV can cause free radicals in skin cells and this is what causes skin cancer, wrinkles, photo-aging, and sun burns. 

This diet will help protect the skin against the damaging effects of UV, without the need for conventional sunscreens. 

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My Sleep Experiments and Favorite Sleep Hacks

Why do we even need sleep?

I remember back in high school my friends discussing the idea of having to sleep was just a caffeine deficiency.

I could never do without sleep.

Actually, I noticed a majority of my problems started with bad sleep and ended with good sleep.

So, let's get into what I've been doing.

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BDNF: 140+ Natural Ways to Increase Brain Derived Neurotrophic Factor

BDNF is important for longterm memory and helps grow new neurons from neural stem cells (neurogenesis). 

BDNF is important for the development of the brain, sensory nervous system and neural development.

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