Mast Cells (Part 3): The Mast Cell-Glia Interaction In Chronic Inflammation

In this post we will focus on the mast cell-glia (microglia, astrocyte, oligodendrocyte) interaction with our body and how they contribute to chronic inflammatory diseases such as CIRS and SALI.

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The 19+ Benefits Of Cyproheptadine (Periactin) With Side Effects And Mechanisms

In this post, we will discuss therapeutic and off-label effects of Cyproheptadine (Periactin), as well as side effects and mechanisms of this drug.

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32+ Zeitgebers (Biological Cues) And How To Enhance Your Circadian Rhythm

Right now as I write this, I am watching the morning sun, sitting on a bench in Dolores Park with my shirt off an laptop out - in 50ºF weather!

Last night I had no sleep as I just traveled from FL to CA and helping my brother pack until 4am… and I woke up around 5am (8am my normal time… thanks jetlag).

That’s why I believe today’s topic of discussion should be circadian rhythm cues, also called Zeitgebers.

Zeitgebers (the German word for “time givers”) are signals that help synchronize the body's circadian clock with the environment.

In this post, we will discuss the most common zeitgebers, how they affect our circadian rhythm, and how we can use them to enhance our sleep, stress, weight, social life, and more.

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How Ciguatoxins Cause CIRS, Brain Fog, & Loss of NAD+

Ciguatoxins are a harmful byproduct of marine life and their exposure can cause both acute and chronic long term neurological effects.

In this post, we will discuss how ciguatoxins can cause CIRS, brain fog, and loss of NAD+.

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The 35+ Benefits Of French Maritime Pine Bark (Pycnogenol, Flavangenol And Oligopin)

n this post, we will discuss the benefits of French Maritime Pine Bark and Pycnogenol as well as their mechanisms of action.

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The 29+ Benefits Of Sophora flavescens (Ku Shen)

Ku shen (sophora flavescens) is a root with powerful effects on cancer, metabolic diseases, neurological disorders and more.

In this post, we will discuss the benefits of ku shen, its caveats, and where to buy ku shen.

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Parvalbumin: Why You Can't Supplement For Fish

In this post, we will discuss what parvalbumin is, how it plays a role in chronic illnesses, and what you can do to  increase it. 

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The 16+ Benefits Of Catuaba (Trichilia Catigua And Other Catuabas)

Catuaba is a powerful plant that can improve depression, anxiety, fatigue, and more.

In this post, we will discuss the different forms of Catuaba (true vs non-true catuabas), the benefits of catuaba, and dosage of catuaba.

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How To Control Your Reticular Activating System

I've always believed in "what you focus on grows... where focus goes, energy flows". - Tony Robbins

The Reticular Activating System (RAS) provides the major pathology for being in the "flow state".

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Do You Have Systemic And Long-term Inflammation? (SALI)

Do you have CIRS that does not go away with the traditional or manipulated versions of the protocol?

In this post, we will discuss what is SALI and how this may be a better way to look at similar chronic diseases.

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Haptens: A Root Cause Of Food Intolerance, Chemical Sensitivity, Skin Sensitivity, And Autoimmunity

Many of my chemically sensitive clients have reactions from inhaling, eating, and skin/air contact with chemicals.

Haptens effect on the immune system supports why they can wear a gas mask in a perfumey room and still get sick.

I haven't seen anyone else online talking about haptens and I've noticed that a lot of my allergies and chemical sensitivities have improved by reducing my hapten exposure.

In study models, haptens can be used in to induce food intolerance, chemical sensitivities, skin disease, and autoimmunity.

In this post, we will discuss the how haptens may have detrimental effects on humans.

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The 8+ Benefits of Hederagenin (with Sources and Derivatives)

In this post, we will discuss the benefits and natural sources of hederagenin and hederagenin derivates. 

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The 14+ Benefits of PeaLut / Glialia (Palmitoylethanolamide + Luteolin)

PeaLut is the combination of two powerful components that when combined can abolish inflammation, increase hippocampal growth, and reduce pain.

In this post, we will discuss the benefits of PeaLut and where to buy it.

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The 28+ Benefits Of Embelin And Its Natural Sources

Embelin suppresses cancer, combats inflammation, ameliorates autoimmunity, and destroys many infectious agents.

It also has anti-diabetic, anti-obesity, neuroprotective, and cardioprotective protective effects.

In this post, we will discuss the MANY benefits of embelin, its natural sources, and some synergies of embelin.

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The 7+ Benefits Of Suvorexant (Belsomra): A Dual Orexin Receptor Antagonist

Suvorexant is a dual-orexin receptor antagonist that improves insomnia.

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All About Histamine H3 Receptors (HRH3/HR3): Genetics, Mechanisms, And Antagonists

Is histamine a villain… or really a superhero?

It really depends on which receptor it works on and where it is in the body.

In this post, we will discuss how to use the 3rd histamine receptor to boost cognition, memory, and attention.

We will first discuss how the histamine receptors work.

Then, we will move onto the benefits (and downsides) of blocking Histamine H3 Receptor's (HRH3 or H3R) activity with natural and pharmacological methods.

Lastly, we will discuss the potential benefits of increasing HRH3 with some agonists, HRH3's mechanism of action, and some important HRH3 SNPs.

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HOMER1, HOMER2, and HOMER3: How These Homologs Promote Strong Synaptic Plasticity

In this post, we will discuss Homer proteins (mainly homer1), their implicated diseases with dysregulation, and some novel ways to help with homeostasis.

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PON1: Increase Longevity And Detox Pesticides with 99+ Ways To Increase Paraoxonase 1

Paraoxonase 1 (PON1) is an enzyme that plays a role in most diseases.

In this post, we will discuss how you can use PON1 to improve overall health, longevity, and detox mechanisms.  

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Are You ApoE4? 88+ Ways To Increase Apolipoprotein E (ApoE)

ApoE is a master regulator for many genes implicated in cholesterol metabolism (such as Alzheimer's Disease and Atherosclerosis).

In this post, we will discuss the benefits and downsides of ApoE, how to determine if you are ApoE2, E3, or E4, and ways to fix it.

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How To Inhibit Lipopolysaccharides (LPS), Lipoglycans, and Endotoxins

Recent data suggests that chronically low levels of circulating LPS may be associated with the development of metabolic diseases such as insulin resistance, type 2 diabetes, atherosclerosis and cardiovascular disease. R

In this post, we will discuss how LPS affects the body and how to reverse endotoxemia.

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