Are You ApoE4? 88+ Ways To Increase Apolipoprotein E (ApoE)

ApoE is a master regulator for many genes implicated in cholesterol metabolism (such as Alzheimer's Disease and Atherosclerosis).

In this post, we will discuss the benefits and downsides of ApoE, how to determine if you are ApoE2, E3, or E4, and ways to fix it.

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Humanin: 7+ Ways To Increase Mitochondria's IGF-1

The term Humanin (HN) was coined by its discoverer, Professor Nishimoto, to denote the potential of this molecule to restore the “humanity” of patients with Alzheimer’s disease. 

Later we have found humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults as well as also improves cardiovascular disease and Alzheimer's disease. 

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How To Have Your Cake And Eat It Too: Calorie Restriction And Fasting Mimetics

Calorie Restriction Mimetics (CRMs) are compounds that can induce the same mechanisms as eating less, without having to actually eat less. 

In this post, we will discuss how to have your cake (food) and eat it too. 

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Hormesis: What Doesn't Kill You Makes You Stronger

When you optimize your body and fix all deficiencies, where is there to go next in enhancing your body?

Well there is hormesis, which is a very powerful tool for enhancing all aspects of your life.

Hormesis, if done properly can strengthen metabolism, longevity, and wellbeing as well as protect you from chronic illness in general.

In this post we will discus what hormesis is, how to do it, and what to watch out for so you can do it properly.

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The Role of DARPP-32 In Addiction, Schizophrenia & Parkinson's Disease

In this post, we will discuss how protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) plays a large role addiction, Parkinson's Disease, schizophrenia, cognition, and cancer. 

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256+ Ways To Increase Dopamine Naturally (Supplements And Genetics)

Dopamine is extremely important for everyday function and plays a much larger role in the body than just bonding, motivation, cognition, emotion, well-being, and movement.

Unfortunately, our environment today is very good at manipulating and hijacking our dopamine system.

In this post we will discuss, how/why dopamine is produced, how chronic inflammation affects dopamine, what are some quick fixes for dopamine, and what are some long lasting dopamine builders, as well how to avoid losing dopamine. 

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Neuropeptides and Autophagy

Two key players in healthy aging are proper neuropeptide signaling and healthy induction of autophagy. R

In this post, we will discuss how neuropeptides either induce or inhibit autophagy.

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The Ketoflex 12/3 Diet (Recipes and Supplements)

The Ketoflex 12/3 diet is an integral part of the Bredesen Protocol to reverse Alzheimer's Disease and Dementia.

In this post, we will be discussing the overall goals of the Ketoflex 12/3 Diet, the recommended foods to eat, recipes to try, how to start the diet and get into ketosis, solving cravings, how to fix dysbiosis, and what supplements are needed that are not in the diet.

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MANF: What Is It And How To Increase Mesencephalic Astrocyte-Derived Neurotrophic Factor

Mesencephalic astrocyte-derived neurotrophic factor (MANF; also known as ARMET or arginine-rich mutated in early stages of tumor) belongs to the fourth family of neurotrophic factors. 

It plays a huge role in repairing neurons and cells after oxidative stress, and has promising uses for the future in neurodegenerative diseases (such as  Parkinson's Disease).

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Why NRF2 Activation Can Make You More Sick

Recent cancer research has helped us understand how the body detoxes.

By studying upregulated genes in tumorous cells, we were able to find the Nuclear Erythroid 2–Related Factor 2 (NRF2) pathway.

NRF2 is a major transcription factor in detoxing the body and keeping it healthy.

In this post, we will discuss the benefits/downsides of NRF2 activation, as well as why NRF2 may be hurting you more than helping you (and what you can do about it).

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BDNF: 140+ Natural Ways to Increase Brain Derived Neurotrophic Factor

BDNF is important for longterm memory and helps grow new neurons from neural stem cells (neurogenesis). 

BDNF is important for the development of the brain, sensory nervous system and neural development.

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