32+ Zeitgebers (Biological Cues) And How To Enhance Your Circadian Rhythm

Right now as I write this, I am watching the morning sun, sitting on a bench in Dolores Park with my shirt off an laptop out - in 50ºF weather!

Last night I had no sleep as I just traveled from FL to CA and helping my brother pack until 4am… and I woke up around 5am (8am my normal time… thanks jetlag).

That’s why I believe today’s topic of discussion should be circadian rhythm cues, also called Zeitgebers.

Zeitgebers (the German word for “time givers”) are signals that help synchronize the body's circadian clock with the environment.

In this post, we will discuss the most common zeitgebers, how they affect our circadian rhythm, and how we can use them to enhance our sleep, stress, weight, social life, and more.

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Torpor And Hibernation Mimetics: Hibernation Induction Triggers, DADLE, and Deltorphins

Hibernation induction trigger (HIT) is a hormone that binds to delta-opioid receptors and has the ability to protect tissues from death, oxygen loss, and more. 

HIT may be beneficial for preserving muscle in those who are bedridden and may be useful for astronauts who are weightless. 

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How Jet Fumes And Hypoxia On Planes Affect The Body

Hypoxia (loss of oxygen) is a major stressor on the body.

On average, one can live ~21 days without food, ~2 days without water, but only a few minutes without oxygen. R

Most studies review long term exposure of hypoxia, but in this post we will discuss what happens to the body on a cellular level when exposed to hypoxia in the short term, such as flying or space travel (in a non-hormetic way).

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How To Have Your Cake And Eat It Too: Calorie Restriction And Fasting Mimetics

Calorie Restriction Mimetics (CRMs) are compounds that can induce the same mechanisms as eating less, without having to actually eat less. 

In this post, we will discuss how to have your cake (food) and eat it too. 

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Hormesis: What Doesn't Kill You Makes You Stronger

When you optimize your body and fix all deficiencies, where is there to go next in enhancing your body?

Well there is hormesis, which is a very powerful tool for enhancing all aspects of your life.

Hormesis, if done properly can strengthen metabolism, longevity, and wellbeing as well as protect you from chronic illness in general.

In this post we will discus what hormesis is, how to do it, and what to watch out for so you can do it properly.

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MANF: What Is It And How To Increase Mesencephalic Astrocyte-Derived Neurotrophic Factor

Mesencephalic astrocyte-derived neurotrophic factor (MANF; also known as ARMET or arginine-rich mutated in early stages of tumor) belongs to the fourth family of neurotrophic factors. 

It plays a huge role in repairing neurons and cells after oxidative stress, and has promising uses for the future in neurodegenerative diseases (such as  Parkinson's Disease).

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Why NRF2 Activation Can Make You More Sick

Recent cancer research has helped us understand how the body detoxes.

By studying upregulated genes in tumorous cells, we were able to find the Nuclear Erythroid 2–Related Factor 2 (NRF2) pathway.

NRF2 is a major transcription factor in detoxing the body and keeping it healthy.

In this post, we will discuss the benefits/downsides of NRF2 activation, as well as why NRF2 may be hurting you more than helping you (and what you can do about it).

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The 3+ Benefits of Prunus Virginiana (Bitterberry Or Western Chokecherry)

In this post, we will discuss the composition and potential of Chokecherries antioxidant capacity. 

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Why You Need To Get Out Into The Sun

In common day western society, we are consistently bombarded by artificial light.

Our workspaces are indoors, powered by fluorescent blue lights (which blue has its own negatives).

We only get sun rarely and it's either partial (such as through glass while driving to work) or too much (single sessions of long periods hanging out at the beach).

We also try to supplement for the sun by taking vitamin D hormone supplements, which is not as bioactive for creating the active form vitamin D.

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