The 7+ Benefits of Rubiscolins (Opioid Peptide From Rubisco)

Rubiscolins are naturally occurring opioid peptides that come from Spinach.

In this post, we will discuss the benefits of Rubsicolin (-5 and -6) and their mechanism of action.

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The 19+ Benefits Of Cyproheptadine (Periactin) With Side Effects And Mechanisms

In this post, we will discuss therapeutic and off-label effects of Cyproheptadine (Periactin), as well as side effects and mechanisms of this drug.

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32+ Zeitgebers (Biological Cues) And How To Enhance Your Circadian Rhythm

Right now as I write this, I am watching the morning sun, sitting on a bench in Dolores Park with my shirt off an laptop out - in 50ºF weather!

Last night I had no sleep as I just traveled from FL to CA and helping my brother pack until 4am… and I woke up around 5am (8am my normal time… thanks jetlag).

That’s why I believe today’s topic of discussion should be circadian rhythm cues, also called Zeitgebers.

Zeitgebers (the German word for “time givers”) are signals that help synchronize the body's circadian clock with the environment.

In this post, we will discuss the most common zeitgebers, how they affect our circadian rhythm, and how we can use them to enhance our sleep, stress, weight, social life, and more.

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The 35+ Benefits Of French Maritime Pine Bark (Pycnogenol, Flavangenol And Oligopin)

n this post, we will discuss the benefits of French Maritime Pine Bark and Pycnogenol as well as their mechanisms of action.

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The 27+ Benefits Of Ecklonia Cava and Phlorotannins

Ecklonia cava is a powerful brown algae that shows promising potential in many metabolic diseases.

In this post, we will discuss the benefits of Ecklonia cava, where to buy it, and its mechanism of action.

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All About Phoenixin: Pros And Cons Of Phoenixin And GPR173

Phoenixin is a peptide that regulates reproductive function, behavior, sensory perception, memory retention, cardiovascular health and food intake.

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How To Increase Healing Of Dura Mater After Lumbar Puncture, Epidural, and Other Injuries

After epidurals or lumbar punctures, Dura Mater can get damaged, so in this post, we will discuss how to enhance its healing in the early phases after injury and other treatments later on.

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The 22+ Benefits Of Oxymatrine (With Natural Sources, Synergies, And Mechanisms)

Oxymatrine has shown to have anti-arrhythmic, immune regulatory, and anti-tumor properties and is used in China for treatment of viral hepatitis, cancer, cardiac diseases (such as viral myocarditis), and skin diseases (such as psoriasis and eczema). R

In this post, we will discuss the many benefits of oxymatrine, its natural sources, and its mechanisms.

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The 7+ Benefits of KIOM-79 (with Alternatives)

KIOM-79 is a potent AGE-abolisher and may improve eysight.

In this post, we will discuss the benefits of KIOM-79 and an alternative way to source its ingredients.

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The 27+ Benefits Of Matrine (with Natural Sources And Mechanisms)

Matrine is a very powerful alkaloid that has many neuropharmalogical benefits.

In this post, we will discuss matrine's benefits, natural sources for it, and some of matrine's 195+ mechanisms.

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The 8+ Benefits Of Sophoraflavanone G (with Mechanisms and Natural Sources)

Sophoraflavanone G (SG) is a flavonoid and phytoncide with powerful effects on quenching inflammation and fighting microbes.

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How GPR84 Senses And Potentiates Inflammation

GPR84 is an inflammation sensor that plays a role in endotoxemia, brain injuries, and obesity.

In this post, we will discuss how to regulate GPR84's function. 

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The 28+ Benefits Of Embelin And Its Natural Sources

Embelin suppresses cancer, combats inflammation, ameliorates autoimmunity, and destroys many infectious agents.

It also has anti-diabetic, anti-obesity, neuroprotective, and cardioprotective protective effects.

In this post, we will discuss the MANY benefits of embelin, its natural sources, and some synergies of embelin.

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All About Histamine H3 Receptors (HRH3/HR3): Genetics, Mechanisms, And Antagonists

Is histamine a villain… or really a superhero?

It really depends on which receptor it works on and where it is in the body.

In this post, we will discuss how to use the 3rd histamine receptor to boost cognition, memory, and attention.

We will first discuss how the histamine receptors work.

Then, we will move onto the benefits (and downsides) of blocking Histamine H3 Receptor's (HRH3 or H3R) activity with natural and pharmacological methods.

Lastly, we will discuss the potential benefits of increasing HRH3 with some agonists, HRH3's mechanism of action, and some important HRH3 SNPs.

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PON1: Increase Longevity And Detox Pesticides with 99+ Ways To Increase Paraoxonase 1

Paraoxonase 1 (PON1) is an enzyme that plays a role in most diseases.

In this post, we will discuss how you can use PON1 to improve overall health, longevity, and detox mechanisms.  

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How To Run While Sitting Down: Exercise Mimetics

Exercise Mimetics are novel ways of getting the benefits of exercising, without having to exercise.

In this post, we will discuss the benefits and mechanisms of exercise and some possible ways to replace exercise. 

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Humanin: 7+ Ways To Increase Mitochondria's IGF-1

The term Humanin (HN) was coined by its discoverer, Professor Nishimoto, to denote the potential of this molecule to restore the “humanity” of patients with Alzheimer’s disease. 

Later we have found humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults as well as also improves cardiovascular disease and Alzheimer's disease. 

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DJ-1/PARK7: How To Revive NRF2 (with 27+ Ways To Increase Protein Deglycase DJ-1)

Protein deglycase DJ-1 (DJ-1), also known as Parkinson disease protein 7 (PARK7) is a master regulator of redox status.

In this post, we will discuss how DJ-1 increases dopamine, enhances mitochondria, and combats most oxidative-stress related diseases. 

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How To Have Your Cake And Eat It Too: Calorie Restriction And Fasting Mimetics

Calorie Restriction Mimetics (CRMs) are compounds that can induce the same mechanisms as eating less, without having to actually eat less. 

In this post, we will discuss how to have your cake (food) and eat it too. 

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How To Inhibit Lipopolysaccharides (LPS), Lipoglycans, and Endotoxins

Recent data suggests that chronically low levels of circulating LPS may be associated with the development of metabolic diseases such as insulin resistance, type 2 diabetes, atherosclerosis and cardiovascular disease. R

In this post, we will discuss how LPS affects the body and how to reverse endotoxemia.

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