32+ Zeitgebers (Biological Cues) And How To Enhance Your Circadian Rhythm

Right now as I write this, I am watching the morning sun, sitting on a bench in Dolores Park with my shirt off an laptop out - in 50ºF weather!

Last night I had no sleep as I just traveled from FL to CA and helping my brother pack until 4am… and I woke up around 5am (8am my normal time… thanks jetlag).

That’s why I believe today’s topic of discussion should be circadian rhythm cues, also called Zeitgebers.

Zeitgebers (the German word for “time givers”) are signals that help synchronize the body's circadian clock with the environment.

In this post, we will discuss the most common zeitgebers, how they affect our circadian rhythm, and how we can use them to enhance our sleep, stress, weight, social life, and more.

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How Ciguatoxins Cause CIRS, Brain Fog, & Loss of NAD+

Ciguatoxins are a harmful byproduct of marine life and their exposure can cause both acute and chronic long term neurological effects.

In this post, we will discuss how ciguatoxins can cause CIRS, brain fog, and loss of NAD+.

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Parvalbumin: Why You Can't Supplement For Fish

In this post, we will discuss what parvalbumin is, how it plays a role in chronic illnesses, and what you can do to  increase it. 

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How To Control Your Reticular Activating System

I've always believed in "what you focus on grows... where focus goes, energy flows". - Tony Robbins

The Reticular Activating System (RAS) provides the major pathology for being in the "flow state".

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What Is Toxin Bioaccumulation? How Biotoxin Accumulation Causes (Reversible) Chronic Dysfunction

Recent evidence suggests that 70–90% of chronic disease is likely related to environmental determinants. 

In this post, we will discuss how biotoxin accumulation may cause chronic illness.

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The 7+ Benefits Of Suvorexant (Belsomra): A Dual Orexin Receptor Antagonist

Suvorexant is a dual-orexin receptor antagonist that improves insomnia.

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All About Histamine H3 Receptors (HRH3/HR3): Genetics, Mechanisms, And Antagonists

Is histamine a villain… or really a superhero?

It really depends on which receptor it works on and where it is in the body.

In this post, we will discuss how to use the 3rd histamine receptor to boost cognition, memory, and attention.

We will first discuss how the histamine receptors work.

Then, we will move onto the benefits (and downsides) of blocking Histamine H3 Receptor's (HRH3 or H3R) activity with natural and pharmacological methods.

Lastly, we will discuss the potential benefits of increasing HRH3 with some agonists, HRH3's mechanism of action, and some important HRH3 SNPs.

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HOMER1, HOMER2, and HOMER3: How These Homologs Promote Strong Synaptic Plasticity

In this post, we will discuss Homer proteins (mainly homer1), their implicated diseases with dysregulation, and some novel ways to help with homeostasis.

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The Role of DARPP-32 In Addiction, Schizophrenia & Parkinson's Disease

In this post, we will discuss how protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) plays a large role addiction, Parkinson's Disease, schizophrenia, cognition, and cancer. 

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256+ Ways To Increase Dopamine Naturally (Supplements And Genetics)

Dopamine is extremely important for everyday function and plays a much larger role in the body than just bonding, motivation, cognition, emotion, well-being, and movement.

Unfortunately, our environment today is very good at manipulating and hijacking our dopamine system.

In this post we will discuss, how/why dopamine is produced, how chronic inflammation affects dopamine, what are some quick fixes for dopamine, and what are some long lasting dopamine builders, as well how to avoid losing dopamine. 

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115+ Ways To Increase Tyrosine Hydroxylase (And What Decreases It)

Tyrosine hydroxylase is a necessary enzyme to create neurotransmitters and protect the body against oxidative stress.

In this post, we will discuss its benefits, downsides, and ways to increase its activity. 

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Balancing Excitatory Amino Acid Transporter Activity

Controlling Excitatory Amino Acid Transporters (EAATs) activity is a novel way to reduce excitotoxicity (neuronal damage due to overactivity) in the brain

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The 18+ Benefits Of Tianma and Gastrodin

Tianma and Its 81+ Major Compounds

Tianma (also called Gastrodia Elata) works on many systems of the body including the brain, liver, heart, eyes, ears, bones, and lungs.

It has many potential benefits in preventing treating common neurological and metabolic disorders such as Alzheimer's, Parkinson's, Huntington's, epilepsy, liver disease, diabetes, neuropathy, and more.

In this post, we are going to be talking about Tianma, its bioactive components, and their benefits.

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How Retinoids Gave Me Panic Attacks And Depression

This post is in a completely different style/language than other posts I've done. 

As a blogger, what do you do after a breakup?

Write about why it happened, of course!

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Inhibiting Nogo-A For Increased Brain Plasticity

Nogo-A is one of the most potent growth inhibitors in the central nervous system.

It is involved in creating new blood cells, developing new stem cells, protecting growth of cancer, and modulating the immune system.

It is highly expressed after adolescent development, traumatic brain injuries, and many myelin-related diseases.

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Adropin: A Predictor of Heart Disease

Preptin, adropin and irisin are three co-workers in the regulation of energy homeostasis. 

Adropin is derived from the Latin roots “aduro” [to set fire to] and “pinquis” [fats or oils]. 

It was first discovered in 2008 by Kumar and his coworkers. 

Peptides secreted from peripheral organs regulate lipid metabolism in key insulin-target tissues and are important for energy homeostasis and maintaining insulin sensitivity. 

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IL-8: 53 Ways to Naturally And Artificially Lower This Chemokine

Interleukin 8 (IL8 or CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. 

IL-8, also known as neutrophil chemotactic factor, has two primary functions: 

It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection.
It also induces phagocytosis once they have arrived.

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