10+ Reasons Why Alcohol Intolerance Happens And How To Build Alcohol Tolerance (Mechanisms And Genetics)

Are you someone who could handle their alcohol until getting sick, then any sort of alcohol in any amount may make you sick?

This is a common problem with those after their immune system has gone haywire.

In this post, I will breakdown and discuss mechanisms behind the loss of tolerance towards alochol

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All About Phoenixin: Pros And Cons Of Phoenixin And GPR173

Phoenixin is a peptide that regulates reproductive function, behavior, sensory perception, memory retention, cardiovascular health and food intake.

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Parvalbumin: Why You Can't Supplement For Fish

In this post, we will discuss what parvalbumin is, how it plays a role in chronic illnesses, and what you can do to  increase it. 

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Do You Have Systemic And Long-term Inflammation? (SALI)

Do you have CIRS that does not go away with the traditional or manipulated versions of the protocol?

In this post, we will discuss what is SALI and how this may be a better way to look at similar chronic diseases.

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Haptens: A Root Cause Of Food Intolerance, Chemical Sensitivity, Skin Sensitivity, And Autoimmunity

Many of my chemically sensitive clients have reactions from inhaling, eating, and skin/air contact with chemicals.

Haptens effect on the immune system supports why they can wear a gas mask in a perfumey room and still get sick.

I haven't seen anyone else online talking about haptens and I've noticed that a lot of my allergies and chemical sensitivities have improved by reducing my hapten exposure.

In study models, haptens can be used in to induce food intolerance, chemical sensitivities, skin disease, and autoimmunity.

In this post, we will discuss the how haptens may have detrimental effects on humans.

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Discoidin Domain Receptors (DDR1 and DDR2): Activators And Inhibitors

DDR1 and DDR2 are tyrosine kinase receptors in the extracellular matrix that mediate mediate cell aggregation.

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Natural Cyclooxygenase 2 (COX-2) Inhibitors (with Genetics and Pathways)

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin.

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X-Linked Inhibitor Of Apoptosis (XIAP) And How To Inhibit XIAP

X-Linked Inhibitor Of Apoptosis (XIAP) has shown to play a role in cancer, longevity, inflammatory resistance, and more.

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What Is Toxin Bioaccumulation? How Biotoxin Accumulation Causes (Reversible) Chronic Dysfunction

Recent evidence suggests that 70–90% of chronic disease is likely related to environmental determinants. 

In this post, we will discuss how biotoxin accumulation may cause chronic illness.

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All About Histamine H3 Receptors (HRH3/HR3): Genetics, Mechanisms, And Antagonists

Is histamine a villain… or really a superhero?

It really depends on which receptor it works on and where it is in the body.

In this post, we will discuss how to use the 3rd histamine receptor to boost cognition, memory, and attention.

We will first discuss how the histamine receptors work.

Then, we will move onto the benefits (and downsides) of blocking Histamine H3 Receptor's (HRH3 or H3R) activity with natural and pharmacological methods.

Lastly, we will discuss the potential benefits of increasing HRH3 with some agonists, HRH3's mechanism of action, and some important HRH3 SNPs.

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HOMER1, HOMER2, and HOMER3: How These Homologs Promote Strong Synaptic Plasticity

In this post, we will discuss Homer proteins (mainly homer1), their implicated diseases with dysregulation, and some novel ways to help with homeostasis.

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Activation And Detoxification 101

In this post, we will discus a brief, technical basic explanation of activation and detoxification - two major mechanisms in oxidative homeostasis.

In the future, I will update this post with more references, a MOA section, genetics, and clearer plans of action. 

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PON1: Increase Longevity And Detox Pesticides with 99+ Ways To Increase Paraoxonase 1

Paraoxonase 1 (PON1) is an enzyme that plays a role in most diseases.

In this post, we will discuss how you can use PON1 to improve overall health, longevity, and detox mechanisms.  

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Are You ApoE4? 88+ Ways To Increase Apolipoprotein E (ApoE)

ApoE is a master regulator for many genes implicated in cholesterol metabolism (such as Alzheimer's Disease and Atherosclerosis).

In this post, we will discuss the benefits and downsides of ApoE, how to determine if you are ApoE2, E3, or E4, and ways to fix it.

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DJ-1/PARK7: How To Revive NRF2 (with 27+ Ways To Increase Protein Deglycase DJ-1)

Protein deglycase DJ-1 (DJ-1), also known as Parkinson disease protein 7 (PARK7) is a master regulator of redox status.

In this post, we will discuss how DJ-1 increases dopamine, enhances mitochondria, and combats most oxidative-stress related diseases. 

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How Jet Fumes And Hypoxia On Planes Affect The Body

Hypoxia (loss of oxygen) is a major stressor on the body.

On average, one can live ~21 days without food, ~2 days without water, but only a few minutes without oxygen. R

Most studies review long term exposure of hypoxia, but in this post we will discuss what happens to the body on a cellular level when exposed to hypoxia in the short term, such as flying or space travel (in a non-hormetic way).

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Why Cannabinoid Hyperemesis Syndrome Happens And What To Do About It

Cannabinoid Hyperemesis Syndrome (CHS) is a syndrome of cyclic episodes of nausea, vomiting, and abdominal pain associated with chronic cannabis usage. R R

In this post, we will discuss the pathology of CHS and how to treat it. 

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How To Increase Tyrosine Aminotransferase (TAT)

Tyrosine aminotransferase (TAT) plays a role in degradation of tyrosine in the body and may contribute to liver disease and mental retardation.

In this post, we will discuss TAT's role in disease and ways to increase or decrease this enzyme. 

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Hormesis: What Doesn't Kill You Makes You Stronger

When you optimize your body and fix all deficiencies, where is there to go next in enhancing your body?

Well there is hormesis, which is a very powerful tool for enhancing all aspects of your life.

Hormesis, if done properly can strengthen metabolism, longevity, and wellbeing as well as protect you from chronic illness in general.

In this post we will discus what hormesis is, how to do it, and what to watch out for so you can do it properly.

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The Role of DARPP-32 In Addiction, Schizophrenia & Parkinson's Disease

In this post, we will discuss how protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) plays a large role addiction, Parkinson's Disease, schizophrenia, cognition, and cancer. 

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