How GPR84 Senses And Potentiates Inflammation

GPR84 is an inflammation sensor that plays a role in endotoxemia, brain injuries, and obesity.

In this post, we will discuss how to regulate GPR84's function. 

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X-Linked Inhibitor Of Apoptosis (XIAP) And How To Inhibit XIAP

X-Linked Inhibitor Of Apoptosis (XIAP) has shown to play a role in cancer, longevity, inflammatory resistance, and more.

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Dr. Denis Wilson - Wilson Temperature Syndrome and Regulating Thyroid Function Without Blood Tests

Dr. Denis Wilson and I discuss how to monitor and regulate thyroid function without the need for blood tests.

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HOMER1, HOMER2, and HOMER3: How These Homologs Promote Strong Synaptic Plasticity

In this post, we will discuss Homer proteins (mainly homer1), their implicated diseases with dysregulation, and some novel ways to help with homeostasis.

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Activation And Detoxification 101

In this post, we will discus a brief, technical basic explanation of activation and detoxification - two major mechanisms in oxidative homeostasis.

In the future, I will update this post with more references, a MOA section, genetics, and clearer plans of action. 

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DJ-1/PARK7: How To Revive NRF2 (with 27+ Ways To Increase Protein Deglycase DJ-1)

Protein deglycase DJ-1 (DJ-1), also known as Parkinson disease protein 7 (PARK7) is a master regulator of redox status.

In this post, we will discuss how DJ-1 increases dopamine, enhances mitochondria, and combats most oxidative-stress related diseases. 

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How To Increase Tyrosine Aminotransferase (TAT)

Tyrosine aminotransferase (TAT) plays a role in degradation of tyrosine in the body and may contribute to liver disease and mental retardation.

In this post, we will discuss TAT's role in disease and ways to increase or decrease this enzyme. 

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Hormesis: What Doesn't Kill You Makes You Stronger

When you optimize your body and fix all deficiencies, where is there to go next in enhancing your body?

Well there is hormesis, which is a very powerful tool for enhancing all aspects of your life.

Hormesis, if done properly can strengthen metabolism, longevity, and wellbeing as well as protect you from chronic illness in general.

In this post we will discus what hormesis is, how to do it, and what to watch out for so you can do it properly.

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The Role of DARPP-32 In Addiction, Schizophrenia & Parkinson's Disease

In this post, we will discuss how protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) plays a large role addiction, Parkinson's Disease, schizophrenia, cognition, and cancer. 

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Vasohibin-1 (VASH1) Fights Cancer And Senescence

Vasohibin-1 (VASH1) is an anti-angiogenic protein that may have benefits in cancer and longevity.

In this post, we will discuss conditions associated with VASH1 activity, its benefits, downsides, and ways to change its expression. 

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Vasohibin-2 (VASH2): A Key Player In Cancer And Chemoresistance

In this post, we will dicuss how vasohibin-2 (VASH2) plays a role cancer progression and chemoresistance.

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Neuropeptides and Autophagy

Two key players in healthy aging are proper neuropeptide signaling and healthy induction of autophagy. R

In this post, we will discuss how neuropeptides either induce or inhibit autophagy.

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Mast Cells (Part 2): Mast Cells And Cancer

In this post we will discuss the angiogenic (growth supporting) factors of mast cells in cancer.

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How To Stop Protein Misfolding (Proteopathy)

I tried folding protein once, but all I got was a ham and cheese sandwich.

In this post we're discussing proteopathy, how proteins can cause chronic disease, and some strategies to prevent it all. 

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MANF: What Is It And How To Increase Mesencephalic Astrocyte-Derived Neurotrophic Factor

Mesencephalic astrocyte-derived neurotrophic factor (MANF; also known as ARMET or arginine-rich mutated in early stages of tumor) belongs to the fourth family of neurotrophic factors. 

It plays a huge role in repairing neurons and cells after oxidative stress, and has promising uses for the future in neurodegenerative diseases (such as  Parkinson's Disease).

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Why NRF2 Activation Can Make You More Sick

Recent cancer research has helped us understand how the body detoxes.

By studying upregulated genes in tumorous cells, we were able to find the Nuclear Erythroid 2–Related Factor 2 (NRF2) pathway.

NRF2 is a major transcription factor in detoxing the body and keeping it healthy.

In this post, we will discuss the benefits/downsides of NRF2 activation, as well as why NRF2 may be hurting you more than helping you (and what you can do about it).

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Estrogen Receptors, Estrogenics, And The Rise of Western Disease (Part 1)

In this post we are going to be discussing estrogen receptors and how estrogen affects the body.

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Why You Need To Get Out Into The Sun

In common day western society, we are consistently bombarded by artificial light.

Our workspaces are indoors, powered by fluorescent blue lights (which blue has its own negatives).

We only get sun rarely and it's either partial (such as through glass while driving to work) or too much (single sessions of long periods hanging out at the beach).

We also try to supplement for the sun by taking vitamin D hormone supplements, which is not as bioactive for creating the active form vitamin D.

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