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Bonus 4
Chapter 44 of 47

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Covid Creates More DNA Damage

There are so many pathways inside the cell that get disrupted by COVID, but ultimately there is DNA damage (like double strand breaks).R

The virus also obstructs the repair cycle of those DNA copies. R

Immune Senescence

Covid causes immune senescence, essentially immune cells that won’t die. R

This is why senolytics, like fisetin and quercetin reduce inflammation and improve survival in COVID patients. R

 
 

ORF6, NSP13, and RRM2

Covid causes histone acetylation of the ORF6, NSP13, and RRM2 genes.

This damage may have an impact on:

  • circadian rhythm R

  • telomere shortening R

Through these two impacts, this increases the speed of the process of epigenetic aging. R

Telomere Shortening

 
 

This process of telomere shortening may also contribute to the severity of COVID. R R

This may be because individuals with short telomeres would have an impaired regenerative response upon SARS-CoV-2 infection, thus leading to more severe and progressive pathologies, such as fibrosis-like pathologies in the lungs, kidney or liver. R

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