Gluten is NOT the Problem - it is ATIs
By Jacob Gordon, INHC, FMT-CThis article contains affiliate links. As an Amazon Associate, MyBioHack earns from qualifying purchases at no extra cost to you. We only link products we research and stand behind.
ATIs make up no more than 4% of wheat proteins, but can trigger powerful immune reactions in the gut that can spread to other tissues in the body.
Celiac vs Gluten Intolerance
Non Celiac Gluten sensitivity was originally described in the 1980s and recently a “re-discovered” disorder characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food. R
What are ATIs?
Amylase trypsin inhibitors (ATIs) can drive intestinal inflammation via activation of toll-like receptor 4. They are found in gluten, such as wheat, barley, or rye ,which triggers small intestinal inflammation. R
How Do They Relate to Gluten?
ATIs represent up to 4% of total wheat protein and are highly resistant to intestinal proteases. R
Specifically, gluten elicits and adaptive Th1-mediated immune response in people who have mutation in HLA-DQ2 ore HLA-DQ8.
ATIs engage the TLR4-MD2-CD14 complex, which will release proinflammatory cytokines in cells from celiac and nonceliac patients.
Therefore, ATI's may fuel inflammation and immune reactions in other intestinal and nonintestinal immune disorders. R R
Gliadin
What Helps?
I don't have an allergy to gluten, but do react to ATIs. When I travel, this is what I use, since it breaks down amylase and gluten proteins.
More Research
- Gluten free diets may have more toxic minerals in them like mercury. R
Jacob Gordon
INHC, FMT-C
Board Certified Health Coach
I spent years battling unexplained chronic illness before discovering biohacking, epigenetics, and functional medicine. Now I share that research at MyBioHack to help others find their own answers.
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Deep-dive chapters and recommended supplements for this topic
Quercetin
500mg 2x/day
Vitamin D3 + K2
5000 IU + 200mcg/day
Magnesium Glycinate
400mg at bedtime






