The 10+ Benefits Of Oak Wood (Robuvit and Quercus Species)

"Barrely" Awake: Combat Fatigue With Robuvit

robuvit french oak wood barrel.jpg

Robuvit and Oak Wood extracts from the Quercus species have shown to have very promising results in combating fatigue in human trials.

In the post, we will discuss the benefits of Quercus species and my experience with supplementing Robuvit. 


  1. Basics Of Oak Wood
  2. Benefits Of Oak Wood
  3. My Experience With Oak Wood
  4. Where To Buy Oak Wood
  5. Caveats And Safety
  6. Mechanism Of Action

Basics Of Oak Wood

For centuries humans have been exposed to many compounds from wine and spirits (cognac and whisky) that matured in various types of containers. R

Ancient Mesopotamians initially used barrels made of palm wood. R

The use of oak for barrel production began around 2000 years ago with early literature from the Roman Empire. R

Eventually, winemakers discovered that wine aging in oak barrels was not only convenient, but also improved wine quality by improving their appearances, flavors and mouth feel, therefore, aging wines in oak barrels became an indispensable part of making high-quality wines. R

Components Of Oak Wood

American white oak (Quercus alba) and French red oak (Quercus robur and Quercus petraea) are three of the most frequently used sources of oak woods. R

Robuvit (french oak) contains a specific profile of tannins (specifically roburin and grandinin) with vescalagin, castalagin, ellagic acid, and gallic acid being the most abundant ellagitannins (ET). R

The gut microbiota metabolizes ET into urolithins, which have antioxidant, anticancer, anti-inflammatory, and cardiovascular beneficial properties. R R R R R RR

Oak wood also contains other phenolic compounds such as vanillic acid, vanillin, syringic acid, syringaldehyde, coniferylaldehyde, sinapic aldehyde, scopoletin, and castalagin. R


Benefits Of Oak Wood

1. Abolishes Fatigue

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Oak wood extract is a powerful agent to reduce fatigue. R

For example, in a pilot study Robuvit supplementation was able to improve mental and energy levels (energy, tiredness, and tension) in healthy human without any unwanted side effects. R

In those with Chronic Fatigue Syndrome (CFS), oak wood (Robuvit 200 mg daily for 6 months) could significantly improve energy levels while reducing plasma free radicals in peripheral blood. R

In those with Burnout Syndrome (BOS), Robuvit (300mg/day) can abolish oxidative symptoms such as emotional drainage, fatigue and intolerance. R

2. Improves Anxiety And Post Traumatic Stress Disorder

Robuvit may help with anxiety. R

In a study, 4 weeks of Robuvit administration was able to improve calmness, energy, and tiredness. R

Robuvit may also help with treatment of Post Traumatic Stress Disorder (PTSD). R

3. Helps With Post-Flu Recovery

Robuvit may be a viable adjunct to flu recovery.

For example, in those with high levels of oxidative stress and fatigue after a period (7-10 days) of flu, oak wood extract was able to improve fatigue levels, increase oxygen saturation, reduce weakness, reduce heart rate, increase attention span, and improve sleep patterns. R

4. Improves Antioxidant Status

Oak wood extract can reduce levels of oxidative stress such as C-Reactive Protein (CRP). R R R

For example, one month intake of Robuvit in daily dose of 300 mg significantly reduced levels of oxidative markers advanced oxidation protein products (AOPP) and lipid peroxides (LP) as well as improving antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). R

5. Enhances Exercise Performance And Recovery

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By reducing oxidative stress and improving energy levels, Robuvit can improve exercise performance and recovery. R

For example, in triathalon runners Robuvit is able to improve postrun muscular pain, cramps, localized pain, straining and the recovery time after exercise. R

6. Reduces Lymphedema

Lymphedema is characterized by swelling of the limbs due to lymphatic disease. R

8-week usage of Robuvit can improve leg swelling significantly: ~15% from 300 mg and ~18.9% from 600 mg. R

7. Remediates Alcoholic Liver Failure

Robuvist can combat the damaging effects of alcohol on the liver, thus preventing hepatitis and liver failure. R

It can stabilize ALT, AST, ALP, bilirubin, GGT, and ESR levels post heavy alcohol consumption and enhance liver regeneration. R

8. May Combat Detrimental Effects Of Air Pollution 

Vitachelox (a combination of grape seed extract, green tea extract, oak wood/bark extract) applied to the skin may be able to combat skin damage induced by air pollution. R

9. Counters Vascular Disease


Robuvist can significantly reduce high levels of homocysteine and cysteine, two amino acids that play a role in atherosclerosis or heart failure. R 

10. Abolishes Kidney Disease

Robuvit can improve kidney function as well as prevent albuminuriaR

For example, in subjects with Temporary Kidney Dysfunction (TKD), Robuvit was able to normalize albumin levels in the urine. R

My Experience With Oak Wood

Supplementing French Oak Wood Extract for 4 weeks has significantly improved my energy levels and prevented any major dips in energy.

Where To Buy Oak Wood


Robuvit is standardized and specified to contain at least 20% of roburins (A, B, C, D, and E) including grandinin. R

Human trials have shown benefits ranging from 200-600mg per day.

Oak Wood Goes Well With:

Caveats And Safety

Oak wood extract has shown to be safe.

For example, no unwanted side effects were observed neither during 4-week consumption of the oak wood extract by the volunteers nor after 2 weeks of wash-out period. R

Other human trials have shown no adverse effects. R 

Mechanism Of Action


  • Increases ADAM21 R
  • Increases Albumin R
  • Increases ANAPC5 R
  • Increases APOBE3CA R
  • Increases AREG R
  • Increases ARF3 R
  • Increases Bilirubin R
  • Increases B3GNT5 R
  • Increases CANX R
  • Increases CASZ1 R
  • Increases CAT R
  • Increases CBX3 R
  • Increases CDC26 R
  • Increases CD69 R
  • Increases C1D R
  • Increases EIF4E3 R
  • Increases ELMO1 R
  • Increases EPCAM R
  • Increases GGT R
  • Increases GPC2 R
  • Increases HNRNPC R
  • Increases HOMER2 R
  • Increases HSD3B1 R
  • Increases IL10RA R
  • Increases JTB R
  • Increases KARS R
  • Increases LYZL2 R
  • Increases MT-ND2 R
  • Increases NARS R
  • Increases FNTA R
  • Increases NONO R
  • Increases NPM1 R
  • Increases PRPF8 R
  • Increases PTCH2 R
  • Increases RABGGTB R
  • Increases RBMYD1D R
  • Increases RHOA R
  • Increases RPL11 R
  • Increases RPL17 R
  • Increases RPL24 R
  • Increases RPL30 R
  • Increases RPNS1 R
  • Increases RPS7 R
  • Increases SART1 R
  • Increases SART3 R
  • Increases SEPT2 R
  • Increases SERPIND2 R
  • Increases SLC25A43 R
  • Increases SMC4 R
  • Increases SMNDC1 R
  • Increases SNX32 R
  • Increases SOD R
  • Increases TAF1D R
  • Increases TARDBP R
  • Increases TMED2 R
  • Increases TP53TG3 R
  • Increases USP22 R
  • Increases ZNF259 R
  • Increases ZNF28 R
  • Increases ZNF487P R
  • Increases ZNF492 R
  • Reduces ACTR3C R
  • Reduces ALP R
  • Reduces ALT R
  • Reduces ANAPC5 R
  • Reduces AOPP R
  • Reduces ARF3 R
  • Reduces AST R
  • Reduces ATP6 R
  • Reduces CAMTA2 R
  • Reduces CANX R
  • Reduces CBX3 R
  • Reduces CCL4 R
  • Reduces CD69 R
  • Reduces CRP R
  • Reduces CYP1A1 R
  • Reduces Cysteine R
  • Reduces C1D R
  • Reduces C22orf28 R
  • Reduces DEPDC5 R
  • Reduces EFCAB4B R
  • Reduces EIF3D R
  • Reduces EIF3F R
  • Reduces EIF4G2 R
  • Reduces EPCAM R
  • Reduces ESR R
  • Reduces FAU R
  • Reduces FMN1 R
  • Reduces FNTA R
  • Reduces GUK1 R
  • Reduces HNRNPC R
  • Reduces HNRNPM R
  • Reduces Homocysteine R
  • Reduces HRNPC R
  • Reduces HSD3B1 R
  • Reduces IK R
  • Reduces ILF2 R
  • Reduces IL10RA R
  • Reduces IL18R1 R
  • Reduces KARS R
  • Reduces LP R
  • Reduces MYST2 R
  • Reduces NARS R
  • Reduces NONO R
  • Reduces NPM1 R
  • Reduces PDE5A R
  • Reduces PSMB2 R
  • Reduces PTH2R R
  • Reduces RASA4 R
  • Reduces RHOA R
  • Reduces RPL4 R
  • Reduces RPL11 R
  • Reduces RPL24 R
  • Reduces RPL34 R
  • Reduces RPS27A R
  • Reduces SART1 R
  • Reduces SART3 R
  • Reduces SEPT2 R
  • Reduces SLCO4C1 R
  • Reduces SMNCD1 R
  • Reduces SNX3 R
  • Reduces SNX32 R
  • Reduces TARDBP R
  • Reduces TCEB2 R
  • Reduces TMED2 R
  • Reduces USP22 R
  • Reduces V0B R
  • Reduces XCL1 R
  • Reduces ZNF259 R
  • Reduces ZNF737 R


  • Robuvit affects ribosomes, cell cycle, and spliceosome pathway. The effects of Robuvit on stimulation of ribosomal activity and protein translation are suggested to be involved in relieving fatigue in healthy volunteers and chronic fatigue syndrome in patients. R