How To Increase Tyrosine Aminotransferase (TAT)
By Jacob Gordon, INHC, FMT-CThis article contains affiliate links. As an Amazon Associate, MyBioHack earns from qualifying purchases at no extra cost to you. We only link products we research and stand behind.
Tyrosine aminotransferase (TAT) also known as tyrosine transaminase, plays a role in the degradation of tyrosine in the body and may contribute to liver disease and mental retardation.
In this post, we will discuss TAT's role in disease and ways to increase or decrease this enzyme.
Basics
During the synthesis of catecholamines, tyrosine is either converted into dopamine and norepinephrine by tyrosine hydroxylase (TH) or degraded by tyrosine aminotransferase (TAT). R
This converts tyrosine into 4-Hydroxyphenylpyruvic acid (4-HPPA). R
Inhibition of TAT causes higher levels of tyrosine in the blood and brain. R
TAT is present in the liver, heart, brain, and kidneys. R R R
TAT Activity And Disease
TAT activity can cause Tyrosinemia type II (Richner-Hanhart syndrome, RHS) can cause mental retardation, and elevated blood tyrosine levels. R
Fish Oil can prevent increased DNA damage in the striatum and hippocampus from Tyrsoinemia type II. R
N-Acetyl-Cysteine (NAC) and deferoxamine (DFX) can decrease the neurodegenerative effects of L-tyrosine on mitochondria in the brain in those with Tyrsoinemia type II. R R
In Tyrosinemia type II, tyrosine crystals can deposit in the cornea and results in corneal inflammation. R
3. TAT In The Heart
In the heart, TAT suppresses TH levels and decreases NE levels in the heart. R
Inhibiting high levels of TAT may help with the heart's ability to contract. R
4. TAT In The Reproductive System
Estrogen can affect the way TAT activity expresses in the ovaries, contributing to ovarian cancer. R
What Increases TAT?
What Decreases TAT?
Mechanism Of Action
Jacob Gordon
INHC, FMT-C
Board Certified Health Coach
I spent years battling unexplained chronic illness before discovering biohacking, epigenetics, and functional medicine. Now I share that research at MyBioHack to help others find their own answers.
Book a ConsultationRelated Protocols & Supplements
Deep-dive chapters and recommended supplements for this topic
Electrolyte Complex
1 scoop/day
CoQ10
200mg/day
Magnesium Glycinate
400mg at bedtime
