The 5+ Benefits of KIOM-MA And KIOM-MA128 (with Alternatives)


In this post, we will discuss KIOM-MA as a treatment for many inflammatory diseases.



KIOM-MA is a Korean Herbal Medicine used for the treatment of many inflammatory diseases.

KIOM=MA128 is a the fermented version of KIOM-MA (with Lactobacillus rhamnosus). R

The ingredients of KIOM-MA are:


1. May Help With Inflammatory Bowel Disease

KIOM-MA improve gut permeability by improving tight junctions (TJ) and decreasing inflammation. R 

KIOM-MA may also help with Inflammatory Bowel Disease (IBD). R

In animal models with IBD, fermented KIOM-MA is able to reduce inflammation and improve TJs in the gut. R

2. Reduces Inflammation


KIOM-MA has significant anti-inflammatory effects. R

For example, when subjected to LPS-stimulated inflammation, KIOM-MA can significantly inhibited the expression of inducible nitric oxide synthase (iNOS) cyclooxygenase-2 (COX-2) as well as nitric oxide (NO) prostaglandin E2 (PGE2), matrix metalloprotease-9 (MMP-9), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), nuclear factor-κB (NF-κB) and represses the activity of extracellular signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase (JNK), and mitogen-activated protein kinases (MAPKs). R

3. Fights Atopic Dermatitis

KIOM-MA and KIOM-MA128 can help with Atopic Dermatitis (AD). R 

Oral administration of KIOM-MA and KIOM-MA128 reduces major clinical signs of AD including erythema/darkening, edema/papulation, excoriations, lichenification/prurigo, and dryness. R

KIOM-MA128 can help with hyperpigmentation (as seen in atopic dermatitis). R

For example, KIOM-MA128 can enhance skin whitening as it can inhibit Tyrosinase and Alpha-Melanocyte Stimulating Hormone (alpha-MSH) activity in the skin. R R

4. May Help With Cancer Treatment

KIOM-MA and KIOM-MA128 may have activity against tumors and may be beneficial in cancer treatment. R R

They may have activity on:

  • Colon Cancer R 
  • Lung Cancer R
  • Melanoma R

5. Improves Allergies

matrine allergy.jpg

KIOM-MA128 can help with allergies. R

For example, KIOM-MA128 can inhibit Mast Cell degranulation and release of antigen/IgE (Ag/IgE)

My Experience

I have successfully taken the combination (below) to combat allergies, especially food intolerances.

Where To Get KIOM-MA

I mix these ingredients together:

It can be fermented with Lactobacillus rhamnosus to make KIOM-MA128. R

Fermentation increases arctigenin, arctiin, icariin, and matairesinol, whereas it decreases nodakenin, neolicuroside, and quercitrin. 

Mechanism Of Action


  • Increases Occludin R
  • Increases ZO-1 R
  • Reduces alpha-MSH R
  • Reduces Claudin-1 R
  • Reduces Claudin-2 R
  • Reduces Claudin-7 R
  • Reduces COX-2 R
  • Reduces ERK R
  • Reduces IgE R
  • Reduces IL-6 R R
  • Reduces iNOS R
  • Reduces JNK R
  • Reduces PGE2 R
  • Reduces PKA R
  • Reduces PKCδ R
  • Reduces PLCγ1 R
  • Reduces MAPK R R
  • Reduces MMP9 R R
  • Reduces MLCK R
  • Reduces MLC2 R
  • Reduces MITF R
  • Reduces NF-kB R
  • Reduces NO R
  • Reduces p38 R
  • Reduces TNF-a R R
  • Reduces TRP-1 R
  • Reduces TRP-2 R 


  • MA128 inhibited anchorage-independent colony formation, migration and invasion. R
  • In allergy, KIOM-MA128 not only inhibited activation of LYN, FYN and SYK, known as the rate-limiting proteins of the FcεRI cascade, but also suppressed the phosphorylation of ERK, p38 and JNK, which is related to cytokine expression. R