The 14+ Benefits of PeaLut / Glialia (Palmitoylethanolamide + Luteolin)

Palmitoylethanolamide + Luteolin (PeaLut): 1+1=3

 
 

PeaLut is the combination of two powerful components that when combined can abolish inflammation, increase hippocampal growth, and reduce pain.

In this post, we will discuss the benefits of PeaLut and where to buy it.

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Basics Of PeaLut

PeaLut is the combination of palmitoylethanolamide (PEA), an endogenous fatty acid amide belonging to the N-acylethanolamine family, with the flavonoid luteolin (Lut).

PEA can bind to endocannabinoid receptors and has been shown to inhibit peripheral inflammation, mast cell degranulation, and pain. R R R

PEA has potent anti-inflammatory and neuroprotective effects, but lacks any direct antioxidant activity. R

Luteolin activates many anti-oxidative enzymes, suppresses allergic responses, and inhibits inflammation. R R

The combination of the two (PEA+Lut = PeaLut in a 10:1 ratio), makes them a powerful combo – Co-ultramicronized PEA/luteolin composite (co-ultraPEALut) is more efficacious than PEA or Luteolin alone. R R R R

Microionized versions of PeaLut (co-ultraPEALut) make it easier for them to get into the cell and exert benefits.

 
 

Benefits Of PeaLut

1. Abolishes Neuroinflammation

PeaLut may be stronger than Cannabidiol (CBD) at reducing neuroinflammation (inflammation of the brain).

PeaLut can inhibit mast cells from degranulating and reduce activation of glial cells (thus improving brain fog). R R R

By reducing mast cell degranulation, PeaLut may protect against a leaky Blood-Brain Barrier (BBB). R

Pealut can also reduce neuroinflammation from Lipoploysaccharide (LPS). R

PeaLut may also be useful for those with mast cell disorders, as it can lower levels of tryptaseR

It can also inhibit neutrophil invasion and macrophage induction of pro-inflammatory cytokines (such as IL-1b, IL-6, and TNF-a). R

2. Regulates Neuronal Autophagy

 
 

Autophagy (degradation, elimination, and recycling of the cell) both protects cells when it is moderately activated, yet its excessive activation can induce cell death. R

PeaLut can inhibit autophagy, interestingly by both inhibiting autophagy promoting proteins such as Beclin-1 as well as inducing various autophagy inhibitory proteins such as Mammalian Target Of Rapamycin (mTOR). R

This makes it beneficial for neurodegeneration and neuroinflammation (more discussed later below). R

3. Improves Cognition

Mild Cognitive Impairment (MCI) can affect cognitive function and performance of activities of daily living. R

In a case-study of a 67-year old woman with MCI, a 3-month treatment of PeaLut (Glialia) and at 9-month follow-up showed significant improvement in many neuropsychological tests, such as attentive matrices (AM), Babcock Story Recall Test (BSRT), MiniMental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Rey Auditory Verbal Learning Test (RAVLT), Trail Making Test (TMT), and verbal fluency tests (VFT). R

A SPECT scan of her brain also revealed better blood flow after treatment. R

4. Protects The Brain During Alzheimer's Disease

Activation of glial cells, neuroinflammation, and beta amyloid (Aβ) fibrils are recognized as a prominent neuropathological features of Alzheimer’s Disease (AD). R

PeaLut can reduce neurotoxicity from AB plaques, while improving neurotransmitter and neurotrophic levels in AD models. R R

5. Combats Vascular Dementia

Vascular Dementia (VAD), the second most common cause of cognitive impairment in the population, is a disease that results from reduction in regional cerebral blood flow and involves oxidative stress and inflammation. R

In animal models with VAD, co-ultraPEALut administration could improve learning, memory ability, locomotor activity, and the reciprocal social interaction. R

It also was able to restore the number of hippocampal neurons, increase Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin 3 (NT-3) expression in mice. R

6. Helps With Spinal Cord Injury Treatment

PeaLut has shown to be helpful in the treatment of Spinal Cord Injury (SCI). R R

For example, in mice with SCI, ultraPEALut (1 mg/kg) reduced the severity of trauma induced by compression and improved the motor activity evaluated at 10 days post-injury. R

PeaLut is able to help with neuronal regeneration after SCI. R

As described before, it can increase BDNF and NT-3 as well as Glial Cell-Derived Neurotrophic Factor (GDNF), and Nerve Growth Factor (NGF). R

This benefits survival and differentiation of new neurons and spine maturation. R

7. Improves Traumatic Brain Injury Recovery

By modulating cell death, inflammatory and oxidative stress, as well as improving neurotrophin levels, PeaLut may be beneficial for Traumatic Brain Injury (TBI). R

In animal models, Co-ultraPEALut at low doses (1 mg/kg) compared with PEA alone can exert neuroprotective effects and the combination of both could improve their ability to counteract the neurodegeneration and neuroinflammation induced by TBI. R

8. Improves Stroke Outcome And Recovery

Acute Ischemic Stroke (IS), the most frequent cause of permanent disability in adults worldwide, results from transient or permanent reduction in regional cerebral blood flow and involves oxidative stress and inflammation. R

In rats, Co-ultraPEALut administration after a Middle Cerebral Artery Occlusion (MCAO) can reduce edema and brain infract volume, improve neurobehavioral functions, and reduce expression of pro-inflammatory markers and astrocyte markers. R

In humans, a cohort of 250 stroke patients undergoing neurorehabilitation on either an inpatient or outpatient basis were treated for 60 days with a pharmaceutical preparation of co-ultraPEALut (Glialia) and had improved marks in neurological status, impairment of cognitive abilities, the degree of spasticity, pain, and independence in daily living activities. R

PeaLut can also protect against mast cell-mediated toxicity in stroke. R

9. May Help Prevent Parkinson's Disease

Parkinson's Disease (PD) is a disorder resulting in degeneration (by neuroinflammation and oxidative stress) of dopaminergic neurons. R

In models of PD, PeaLut can protect dopaminergic neurons from cell death and improves Tyrosine Hydroxylase (TH) function. R

10. Improves Remyelination In Multiple Sclerosis

 
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Multiple Sclerosis (MS) is characterized by demyelination and loss of nerve cells in the brain. R

PeaLut can improve remyelination in the brain by promoting the maturation of Oligodendrocyte Precursor Cells (OPCs) and increasing the levels of Myelin Basic Protein (MBP), while improving OPCs survival. R R R

PeaLut also can increase 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase (CNPase) and Platelet-Derived Growth Factor Receptor Alpha (PDGFRα), two markers that mediate growth of oligodendrocytes. R R

Inflammatory insults in the brain increase the of production of acute-phase proteins, such as Serum Amyloid A (SAA), which is found in myelin sheaths. R

PeaLut can protect against neurotoxic SAA inflammation (via inhibition of Saa1). R

11. Combats Arthritis

PeaLut may be beneficial in combatting arthritisR

For example, in mice with Collagen-induced Arthritis (CIA), PeaLut could ameliorate the clinical signs of arthritis by days 26-35 and reduce overall inflammation. R

12. Relieves Pain

By activating Peroxisome Proliferator-Activated Receptor Alpha (PPAR-alpha), PeaLut is strong at reducing pain. R R

For example, in mice subjected to noxious heat (thermal hyperalgesia), daily treatment with PEA-LUT could significantly reduce pain-sensitivity, especially compared to PEA or luteolin alone. R

13. Improves Features Of Autism Spectrum Disorder

PeaLut may be an effective adjunct to treatment of Autism Spectrum Disorder (ASD). R

In animal models of ASD, PeaLut can ameliorate social and nonsocial behaviors from valproic acid-induced ASD. R

In a case study of a 10-year-old male child with ASD, Pealut (Glialia) taken twice a day for a year improved abilities to understand simple commands and executing them with ease as well as improving eye contact and affection behaviors. R

14. May Improve Anxiety And Depression

Low doses of PeaLut may have significant anti-depressant and anti-anxiety effects. R

PeaLut's mood improvement effects may be regulated by hippocampal neurogenesis and neuroplasticity (more BDNF, Bcl2). R

My Experience With PeaLut

For me, Mirica (PeaLut) has been amazing for calmness, brain fog, and pain.

I find Mirica has similar benefits of Brain Gain, but without the need to cycle it.

Where To Buy PeaLut (Glialia And Mirica)

 
 

Glialia (PeaLut) has been used in clinical trails and can be purchased here (usually out of stock).

Mirica is another form of PeaLut (which I now use regularly) and can be purchased here.  

Caveats

Some have reported luteolin to increase irritability in children with ASD. 

Mechanism Of Action

Simple:

  • Increases BCL-2 R R R
  • Increases BDNF R R R
  • Increases CB1 R
  • Increases CB2 R
  • Increases CNPase R
  • Increases GDNF R R
  • Increases HMGCR R
  • Increases IDI1 R
  • Increases MBP R
  • Increases mTOR R R
  • Increases NGF (but reduces it in mast cells thus inhibiting mast cell degranulationR R
  • Increases nNOS R R
  • Increases NT-3 R
  • Increases PDGFRα R
  • Increases PPAR-alpha R
  • Increases PPAR-beta R
  • Increases PPAR-delta R
  • Increases PPAR-gamma R
  • Increases SCD1 R
  • Increases TH R
  • Increases Ugt-8 R
  • Reduces Akt R
  • Reduces Bax R R
  • Reduces Beclin-1 R
  • Reduces Caspase-3 R
  • Reduces Chymase R R
  • Reduces COX-2 R R
  • Reduces GFAP R
  • Reduces IL-1β R R
  • Reduces IL-6 R
  • Reduces iNOS R R R R
  • Reduces JNK R
  • Reduces MAP-LC3 R
  • Reduces MIP-1α R
  • Reduces MIP-2 R
  • Reduces MPO R
  • Reduces NF-kB R
  • Reduces p62 R
  • Reduces SAA1 R
  • Reduces TNF-alpha R R
  • Reduces Tyrpatase R R
  • Reduces 70S6K (although can increase it after TBI) R R

Advanced:

  • Oral treatment with 30 mg/kg of UM-PEA can result in low-medium nanomolar brain concentrations of PEA already shortly after administration (0-15min). R
  • Brain sections from mice treated with co-ultraPEALut showed a marked reorganization of hippocampal CA1 and CA3 regions; treatment also restored the number of hippocampal neurons. R
  • Pre-treatment with co-ultraPEALut significantly reduced inducible nitric oxide synthase and glial fibrillary acidic protein expression, restored neuronal nitric oxide synthase and brain-derived neurotrophic factor and reduced the apoptosis. R
  • In mice after SCI, PeaLut could increase PPARα, PPARβ/δ and PPARγ levels, as well as inhibit iNOS and COX-2, while restoring nNOS. R
  • Pealut decreases p62, which interacts with a central component of the machine autophagy, autophagic marker MAP-LC3, and carries the altered proteins to degradation by autophagy. R
  • PeaLut also decreases degradation of IκBα, thus reducing NF-kb translocation. R