The 4+ Benefits Of ALAnerv (With An Improved Alternative)

ALAnerv's Pontential Role In Redox Control

 
alanerv alternative
 

ALAnerv is a nutritional supplement that has shown promising beneficial effects in improving Stroke, Diabetes, Spinal Cord Injuries, and Painful Bladder Syndrome.

In this post, we will break down what is in ALAnerv, provide an alternative to it, and my experience with the alternative form.

Contents:

  1. Basics And Ingredients Of ALAnerv
  2. Benefits Of ALAnerv
  3. Where To Get ALAnerv And An Improved Alternative
  4. My Experience With This Combination
  5. Caveats And Dosage
  6. Mechanism Of Action

Basics And Ingredients Of ALAnerv

ALAnerv is a nutritional supplement that essentially contains Alpha-lipoic acid, γ-linolenic acid, selenium and vitamin B-complex with vitamin E.

 
 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556909/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556909/

 

Here are the full ingredients: R

  • Alpha-lipoic acid (300 mg)
  • Borago officinalis (300 mg) oil aka Borrage oil
    • Polyunsaturated fatty acids - linoleic acid and gamma-linolenic acid (180 mg)
  • Vitamin E (~7.5mg) as D-alpha-tocopherol on sunflower oil basis (11.177 mg)
  • B complex
    • Vitamin B1 (1.05 mg) as Thiamine mononitrate 1.259 mg 
    • Vitamin B2 (1.2 mg) as Riboflavin 1.320 mg 
    • Vitamin B5 (4.5 mg) as Calcium pantothenate 5.396 mg 
    • Vitamin B6 ( 1.5 mg) as Pyridoxine hydrochloride 2.010 mg
  • Selenium (~25 μg) as Selenomethionine 0.069 mg 
  • Other
    • Fatty acids triglycerides (60 mg)
    • Magnesium stearate (14 mg)
    • Polyglycerol oleate (10 mg)
    • Soya oil and soya lecithine complex (6 mg)
    • Food gelatin (177.940 mg)
    • Glycerol (82 mg)
    • Titanium dioxide (1.520 mg)
    • Iron red oxide (0.130 mg)

Benefits Of ALAnerv

1. May Improve Outcome After Stroke

ALAnerv may improve outcome after StrokeR

First of all, it has shown to improve antioxidant markers (such as SOD and GRed). R

For example, use of ALAnerv (two pills/day for two weeks) resulted in a significant increase in antioxidant genes (such as PON1 activity) in post-acute stroke patients. R

In another study, the use of ALAnerv was able to reduce inflammatory markers (such as IL-1a and IL-6) in post-acute stroke patients. R

2. May Improve Redox Balance

ALAnerv may improve redox status by quenching free radicals and improve antioxidant status. R R

For example, in stroke with Diabetes, ALAnerv was able to reduce oxidants produced from glucose metabolism. R

In another study, after stroke, ALAnerv has shown to decrease fasting Glucose and Oxidized LDL (ox-LDL) levels. R

Alpha-Lipoic Acid from ALAnerv converts into DHLA, which has antioxidant properties via activation of NRF2. R

3. May Assist Movement Spinal Cord Injury 

ALAnerv may have benefit post-Spinal Cord Injury (SCI). R

For example, ALAnerv supplementation in paraplegic patients treated with ALAnerv vs. controls had a statistically significant better increase of motor scores at discharge. R

4. May Improve Painful Bladder Syndrome

ALAnerv may be complimentary in the treatment for Vestibulodynia/Painful Bladder Syndrome (VBD/PBS). R

For example, in a randomized trial with 84 patients, treatment for VBD/PBS with ALAnerv, Omega 3's, and amitriptyline improved symptoms and allowed for lower doses of amitriptyline. R

Where To Get ALAnerv And An Improved Alternative

ALAnerv is by prescription only. R

An Improved Alternative To ALAnerv

Combining these may produce the same effects as ALAnerv:

My Experience With This Combination

When I combine ALA, GLA, fish oil, selenium, with B Vitamins and Vitamin E, I get improved energy.

For example, after a week of taking this combination I have a lot more endurance for skateboarding and can spend more time at the gym.

Caveats And Dosage

ALAnerv is indicated for quenching of free-radicals. R

It is directed for 1 softgel capsule daily and to take Alanerv on a full stomach. R

Mechanism Of Action

Simple:

  • Increases Glo1 R
  • Increases GRed R
  • Increases PON1 R
  • Increases SOD R
  • Reduces Catalase R
  • Reduces Glucose R
  • Reduces GT R
  • Reduces IL-1a R
  • Reduces IL-6 R
  • Reduces ox-LDL R

Advanced:

  • LA inmodulates the PI3K/Akt signalling pathway, allowing for the translocation of GLUT1 and GLUT4 transporters from the cytosol to the plasma membrane in different cells. R
  • LA is reduced to dihydrolipoic acid (DHLA), a potent antioxidant, which is excreted in the extracellular space. R
  • DHLA acts directly through the regeneration of the reduced form of other endogenous antioxidants (vitamins C and E and glutathione) and the complexation of different metal ions. R
  • DHLA acts indirectly through the activation of transcription factor Nrf2, thereby favouring the synthesis of -glutamyl cysteine synthetase, the rate-limiting enzyme involved in glutathione biosynthesis, and increasing the concentration of reduced glutathione. R
  • Gamma-linolenic acid has the same plasma glucose-lowering effect. R