The 7+ Benefits of KIOM-79 (with Alternatives)

KIOM-79: A Powerful RAGE Inhibitor Formula

KIOM-79 is a potent AGE-abolisher and may improve eysight.

In this post, we will discuss the benefits of KIOM-79 and an alternative way to source its ingredients.

 
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Basics

KIOM is a traditional Korean medicine used for a variety of medical purposes, including diabetes and diabetic complications. R

Its ingredients include:

Benefits

1. Inhibits AGEs, Oxidative Stress, and Inflammation

KIOM-79 can reduce the creation of Advanced-Glycation End-Products (AGEs), oxidized byproducts from high blood sugar. R

AGEs play an important role in cell signaling through their interaction with specific receptors, namely, the Receptor for Advanced Glycation End Products (RAGE), which activates adhesion molecules, proinflammatory cytokines, and growth factors, and contributes to the pathogenesis of diabetic complications. R

KIOM-79 is a potent inhibitor of RAGE. R R

KIOM-79 can scavenge intracellular Reactive Oxygen Species (ROS), thus preventing DNA damage and lipid peroxidation. R

KIOM-79 can also activate antioxidant genes by activating the transcription factor, NF-E2 related factor 2 (Nrf2), thus increasing Antioxidant Response Elements (ARE), resulting in higher levels of Heme Oxygenase-1 (HO-1). R

KIOM-79 is also a potent inhibitor of inflammation. R

For example, in LPS-induced macrophages, KIOM-79 can inhibit Inducible Nitric Oxide Synthase (iNOS). R

2. Combats Diabetes

 
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KIOM-79 can reduce AGEs in diabetic models of:

  • Diabetic Cataracts (eyes) R
  • Diabetic Glomerularsclerosis (kidneys) R
  • Diabetic Keratopathy (eyes) R
  • Diabetic Nephropathy (kidneys) R
  • Diabetic Retinopathy (eyes) R

KIOM-79 can also normalize hyperglycemia, ameliorate insulin resistance, improve urinary protein excretion, and stabilize creatinine clearance. R R

3. Improve Eye Function

KIOM-79 can protect pericytes (in the eyes) from oxidative stress-induced apoptosis (death). R

This is because KIOM-79 is very powerful at reducing AGEs in the eyes. R

In the Retinal Pigment Epithelial (RPE), KIOM-79 can inhibit AGE-induced Vascular Endothelial Growth Factor (VEGF) expression, thus improving microvascular function of the eyes. R R

In animal models, KIOM-79 can inhibit the development of diabetic cataracts. R R R

KIOM-79 can also inhibit the development of diabetic keratopathy and prevent DNA damage in the eye. R 

KIOM-79 can also increase Glutathione (GSH) levels in the eyes. R

4. Protects The Pancreas

KIOM-79 can inhibit pancreatic beta-cell death by scavenging free radical and activating antioxidant enzymes (such as NRF2 and HO-1). R R

In beta-cells, KIOM-79 can improve mitochondrial function by increasing ATP levels. R

5. May Improve Psoriasis

 
 

By inhibiting RAGE, reducing accumulation of collagen, and increasing antioxidant enzymes, KIOM-79 may improve Psoriasis. R

6. Protects The Heart

In the heart, KIOM-79 can prevent diabetes-induced myocardial fibrosis (via inhibition of RAGE, TGF-β1, and other profibrotic factors). R

KIOM-79 can also attenuate the expression of inflammatory factors (including NF-κB, MCP-1, VEGF, VCAM-1, and iNOS) in the aortas of rats. R

7. Prevents Kidney Fibrosis

In the kidneys, KIOM-79 can prevent glomerulosclerosis, tubular degeneration, collagen deposition and podocyte apoptosis. R

My Experience

I've been using this combination (below) for a few weeks.

It has definitely improved my eyesight (in general - less flares, microtears, etc). 

Where To Get KIOM-79

I mix these ingredients together:

Mechanism Of Action

Simple:

  • Increases Bcl-2 R R
  • Increases GSH R
  • Increases HO-1 R
  • Increases NRF2 R
  • Increases SOD R
  • Reduces AGEs R
  • Reduces Alpha-Reductase R
  • Reduces AlphaB-crystallin R
  • Reduces A-P1 R
  • Reduces Bax R
  • Reduces Caspase-3 R
  • Reduces ERK R
  • Reduces Fibronectin R R
  • Reduces iNOS R R
  • Reduces MAPK R R
  • Reduces NF-kb R R R
  • Reduces PKCa/b R
  • Reduces RAGE R
  • Reduces Smad2/3 R
  • Reduces TGF-b1 R R
  • Reduces TGF-b2 R
  • Reduces VEGF R

Advanced:

  • KIOM-79 attenuated caspase-3 expression and AGEs accumulation in the retina. R
  • KIOM-79 could inhibit vascular endothelial growth factor (VEGF) expression in human retinal pigment epithelial (RPE) cells cultured under high glucose. R
  • KIOM-79 attenuated oxidative DNA damage, NF-κB activation and Bax overexpression in the cornea. R
  • KIOM-79 inhibited the translocation of cytochrome c from the mitochondria to the cytosol and elevated the ATP level. R
  • KIOM-79 augments the cellular antioxidant defense capacity through induction of HO-1 via the Akt-Nrf2-ARE signaling pathway, thereby protecting cells from streptozotocin-induced oxidative stress. R