Do You Have Systemic And Long-term Inflammation? (SALI)

SALI:  Systemic And Long-Term Inflammation

SALI systemic and longterm inflammation.jpg

Do you have CIRS or other chronic issues that do not resolve with the traditional or adjusted treatments?

In this post, we will discuss what is SALI and how this may be a better way to look at similar chronic diseases.


  1. Is This Rebranded CIRS?
  2. What Is SALI?
  3. My Experience With SALI
  4. Focal (FALI) Vs Systemic (SALI)
  5. SALI Biomarkers
  6. Thoughts On Treatment

Is This Rebranded CIRS?

CIRS isn’t technically the best way to address what happens in the body as there are a multitude other diseases/patholgies that have the same biomarkers as CIRS such as:

  • Aging
  • Neuroinflammation such as Alzheimer’s Disease, Parkinson’s Disease, MS Stroke, TBI, SCI, and Concussions
  • Autoimmunity, Immune Polarization
  • CFS/ME and FM
  • Depression
  • Infections such as Dysbiosis, Endotoxemia, Lyme, Viruses
  • Metabolic Disorders, Obesity, Liver Disease, Fibrosis
  • Mitochondrial Disease
  • Pollution-related Diseases
  • Redox Problems, Oxidative Stress
  • Sickness Behavior

What Is SALI?

Neither SALI, nor CIRS, are clinical diagnoses (although SIRS is), but I think SALI may help give us a better indication of what is the problem.

I prefer to use the term Systemic And Longterm Inflammation, or SALI (pronounced Sally) for short, to recognize what is happening.

Chronic Inflammatory Response Syndrome (CIRS) indicates that the body is responding to something previous or ongoing, whereas SALI indicates what I believe is truly going on: inflammation that has gone on for a long time and can reach mostly anywhere in the body (see below for FALI vs SALI).

This may be due to a variety of problems: epigenetic switches, infections, chemicals, autoimmunity, haptens, antibodies, lectins, food intolerances, hypoxia, injury, etc…you get the point.

When the body is stuck in inflammation for so long, new symptoms appear because the adaptive immune system signals genes that were once always silent to turn on:

  • In the body (overall), this causes T-cell dysregulation (TH1, TH2, TH9, TH17, TH22, TFH), redox imbalances and thus co-factor depletion (e.g. BH4).
  • In the brain, this causes neuroinflammation (glial activation and neurotrophic loss), BBB permeability, and oxidation of certain areas (e.g. hippocampus = AD, SN = PD, SCN = leptin resistance, thalamus = histamine issues, etc).
  • In the gut, this can cause dysfunction of communication of gut-brain peptides, intestinal permeability and higher amounts of TLRs on cells (negative feedback loops).
  • In tissue (general),  this can contribute to fibrosis, hormonal/peptide resistance, TMR dysfunction, and hypoxia (intracellular).

To be honest, SALI also sounds less intimidating. 

My Experience With SALI

One of my major problems has been with SALI.

I had symptoms of CIRS, but a lot of the areas of my brain and transcription reports showed a different pathology.

I had suffered from mold exposure while growing up, getting dysbiosis in my late teens, and multiple concussions.

Focal (FALI) Vs Systemic (SALI)

SALI can also develop in certain areas of the body causing Focal inflammation (FALI) of the area (autoantibodies to a certain area).

SALI Biomarkers

What kind of biomarkers should you look at?

Here are some possible SALI biomarkers:

  • ADH
  • EPO
  • Ferritin
  • GFAP
  • HMGB1
  • HsCRP
  • IGF-1
  • IFN-g
  • IL-1b/4/6/8/9/10/17/22
  • KYNA
  • Lactate
  • Leptin
  • LPO
  • MMP-2/9
  • Myelin Basic Protein
  • NFP
  • NGF
  • Procalcitonin
  • SNTF
  • S100β
  • TGF-b1
  • TNF-a
  • UCHL1
  • VEGF
  • VIP

Thoughts On Treatment

When treating for SALI, diagnostic tools are very important and no branded "protocol" should be followed.

Follow the "whatever is best for the patient/client" protocol.

I will update this post with more of my thoughts and conclusions in the future.