The 6+ Benefits Of Sophoflavescenol (With Natural Sources And Mechanisms)

Sophoflavescenol: A Cancer-Fighting Flavonol

In this post, we will discuss natural sources of sophoflavescenol and its benefits. 

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Basics Of Sophoflavescenol

Sophoflavescenol is a prenylated flavono from Sophorae and Albizia species.

It has shown to have many potential benefits ranging from vascular control to blood sugar regulation.


Benefits Of Sophoflavescenol

1. Reduces Blood Sugar

Sophoflavescenol may be beneficial for controlling blood sugar in Diabetics. R

Sophoflavescenol is an Aldose Reductase (AR) inhibitor and can suppress hyperglycemia. R R

2. May Fight Alzheimer's Disease


Sophoflavescenol may be beneficial for Alzheimer's Disease (AD).

Sophoflavescenol is a potent inhibitor of some major disrupted mechanisms in AD - e.g. inhibits AR (discussed above), Advanced Glycation End-Products (AGEs), Beta-secretase 1 (BACE1), Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE). R

3. May Improve Vascular Function

Sophoflavescenol may have benefits in improving vascular function and erectile dysfunction as it is a naturally occurring Cyclic Guanosine Monophosphate (cGMP)-Specific Phosphodiesterase Type 5 (PDE5) inhibitor. R

4. Combats Cancers


Sopholavescenol may have antitumor activity without severe side effects. R

Sopholavescenol has anticancer activity against:

  • Colorectal Cancer R
  • Leukemia R
  • Lewis lung Carcinoma R

5. Has Antioxidant Properties

Sophoflavescenol has notable anti-inflammatory activity by inhibiting Nitric Oxide (NO) generation and tert-butylhydroperoxide-induced Reactive Oxygen Species (ROS) generation. R

6. May Act As A Sunscreen Alternative

Sophoflavescenol may have benefits in defending against UV radiation from the Sun and be a Sunscreen Alternative.

Sophoflavescenol can absorb ~430 nm, although it can reduce the activity of Tyrosinase. R R

My Experience With Sophoflavescenol

...currently testing albizia and sophora extracts...

Natural Sources Of Sophoflavescenol



Toxic effects from use of Sophora flavescens root may include nausea, dizziness, vomiting, constipation, spasms, disturbance of speech, irregular breathing, respiratory failure and death. R

Mechanism Of Action


  • Increases Caspase-3 R
  • Reduces AChE R
  • Reduces AGE R
  • Reduces AR R
  • Reduces BACE1 R
  • Reduces BChE R
  • Reduces NO R
  • Reduces PDE3 R
  • Reduces PDE4 R
  • Reduces PDE5 R
  • Reduces ROS R
  • Reduces Tyrosinase R


  • Sophoflavescenol did not show marked inhibition against LPS-induced SEAP expression despite the significant concentration-dependent inhibition of NO production. R
  • It exerted notable anti-inflammatory activity in RAW 264.7 cells through the inhibition of ROS and NO generation rather than the suppression of NF-κB activation. R