The 4+ Benefits Of Zhichan Decoction

Zhi Chan: Sustained Dopamine For Parkinson's


Zhichan (Zhi-Chan) is a Chinese herbal medicine that has shown to clinically improve the symptoms of patients with Parkinson's Disease, such as gait disturbances, tremor, speech disorder, self-care ability, bimanual movements, and writing disorders. R


  1. Basics
  2. Benefits Of Zhichan
  3. Caveats
  4. How To Make Zhichan
  5. Mechanism Of Action


Zhichan is composed of: R

Benefits Of Zhichan

1. Increases Dopamine Levels

Zhichan can increase dopamine synthesis in the brain by two main mechanisms:

  • Increasing Tyrosine Hydroxylase (TH) - creates more dopamine R
  • Reducing Monoamine Oxidase B (MAOB) - inhibits dopamine reuptake/breakdown R

Zhichan may also be useful for promoting growth of neural stem cells into dopaminergic neurons. R

2. May Treat Parkinson's Disease


Zhichan protects the brain in Parkinson's Disease (PD). R

For example, in rodent models of Parkinson's Disease (PD) that are injected with the 6-hydroxy-dopamine, a chemical insult to the substantia nigra, Zhichan can normalize dopamine levels by secretion of striatal dopamine and its metabolite homovanillic acid. R

Zhichan can also reduce inflammatory markers (IL-1b and TNF-α) in models of PD. R

3. Has Antioxidant Properties

Zhichan can increase antioxidant levels in the brain. R

It can increase levels of Superoxide Dismutase (SOD), while reducing Malondialdehyde (MDA). R

4. Protects Cells From Death

By regulating signal transduction protein expression (such as p53 and BCL2), Zhichan can inhibit apoptosis (cell death). R


Nothing observable although studies have only been in animal models.

How To Make Zhichan

These are the ingredients:

How To Use Zhichan:

In rodents, the TH gene expression in the substantia nigra began to increase at 10 days after the administration of Zhichan powder and reached a peak at 20 days. R

Mechanism Of Action


  • Increases  BCL2 R
  • Increases DA R
  • Increases DOPAC R
  • Increases HVA R 
  • Increases IL-6 R
  • Increases SOD R
  • Increases TH R
  • Reduces Bax R
  • Reduces Caspase-3 R
  • Reduces Caspase-8 R
  • Reduces Cytochrome C R
  • Reduces Fas R
  • Reduces IL-1b R
  • Reduces MAOB R
  • Reduces MDA R
  • Reduces p53 R
  • Reduces TNF-alpha R
  • Reduces TNFR1 R


  • Zhichan regulates the expression of monoamine oxidase B and tyrosine hydroxylase in the substantia nigra of Parkinson’s disease rats, and facilitate the secretion of striatal dopamine and its metabolite homovanillic acid, resulting in a neuroprotective effect on substantia nigra neurons in Parkinson’s disease rats. R
  • Zhichan capsules have a down-regulation on the expression IL-1 β and TNF-α mRNA and an up-regulation on IL-6 and the T, B lymphocytes in PD mouse. R