The 10+ Benefits Of Java Tea (Orthosiphon stamineus)

Orthosiphon Stamineus For Cancer And Cognition 

 
orthosiphon stamineus
 

In this post, we will discuss the benefits of Java (Orthosiphon stamineusis), my experience with Java, and where to get the best form. 

Contents:

  1. Basics
  2. Benefits Of Java
  3. My Experience And Where To Get Java
  4. Caveats
  5. Mechanism Of Action
  6. More Research

Basics

Java (orthosiphon stamineus), unrelated to coffee and computers, is a medicinal herb used in southeast Asia to treat various inflammatory diseases such as cancer, hepatitis, jaundice, gout, rheumatism, abdominal pain, psoriasis, hyperlipidemia, diabetes, and kidney stones. R R

In Europe, java is commonly used to improve general health and fitness. R

It is also referred to as Cat’s whiskers tea, aka “Misai Kucing”. R

 
 

Benefits of Java

1. Improves Cognition

Java may enhance via blockade of adenosine A1 (different than caffeine) and A2A receptors (similar to caffeine). R R

It may help with age-related deficits in short-term memory. R

Oleanic acid (from Java) can protect against neuronal death induced by beta-amyloid (pathology of Alzheimer's Disease) in mice. R

Ursolic acid (also found in Java) reduces neuroinflammation and oxidative stress in the brain. R R

2. Treats Diabetes

Java can improve diabetes. R

It enhances insulin release, reduces blood glucose levels, improves HDL cholesterol levels, and inhibits pancreatic α-amylase and intestinal α-glucosidase, two enzymes affect the absorption of starch and uptake of glucose. R R R R

3. Regulates Kidney Function

Java has diuretic properties. R R R

By regulating amino acid output and choline metabolism, java can protect against oxalate-induced kidney injury. R

It may help with gout by increasing excretion of uric acid. R

4. Has Antimicrobial Activity

 
java tea biofilms
 

By inhibiting quorum sensing, java can inhibit biofilms and reduce the susceptibility of bladder/kidney infections. R

Java has antibacterial activity against:

  • Bacillus subtilis R
  • Escherichia coli R
  • Klebsiella pneumoniae R
  • Micrococcus luteus R
  • Vibrio parahaemolyticus R

It also has anti-fungal activity against:

  • Candida albicans R

By improving the immune system, java can protect against Staphylococcus aureus infection. R

Java also helps reduce fevers, comparably to Acetominophen (Tylenol). R

    5. Improves Inflammation

    Java can improve symptoms of arthritis and reduce swelling. R

    By reducing inflammation, java can enhance bone formation and collagen synthesis and may be beneficial for postmenopausal osteoporosis. R

    Java can improve inflammation by its ability to inhibit pro-inflammatory cytokines and COX-2. R

    High doses of java may reduce pain. R

    6. Reduces Weight Gain

    Java possesses anti-obesity effects. R

    For example, in animal models fed a high-fat diet, java could prevent weight gain and obesity. R

    Java's anti-obesity effects can be enhanced with PTP1B inhibitors (such as ursolic acid and berberine). R

    7. Improves Vascular Function

     
    orthosiphon stamineus heart
     

    Java has vasorelaxation activity. R

    It can protect against hypertension by decreasing blood pressure. R

    For example, in a randomized clinical trail, Java was able to reduce systolic/diastolic blood pressure and reduce pulse pressure. R

    8. Protects The Liver

    Java can prevent cirrhosis (scarring) of the liver similarly to Milk Thistle. R

    In studies where rats were exposed to Thioacetamide (hepatotoxic chemical), java could reduce the elevation of ALT, AST, ALP, and Bilirubin and increase total protein and Albumin. R

    9. Protects The Gut Against Alcohol

    By increasing mucus production, java can protect the gut against ulceration from alcohol consumption. R

    10. Combats Cancer 

    Java has anti-tumor activity against:

    • Breast Cancer R R
    • Colon Cancer R
    • Prostate Cancer R

    Java is a potent inhibitor of vascular endothelial growth factor (VEGF), thus suppressing tumor growth. R

    My Experience And Where To Get Java

     
     
    • Tea - Increases my energy in the morning and clears brain fog. 
    • Supplement Form - I get similar effects as the tea, but is clearly more potent.

    Caveats

    In rats, the oral lethal dose is more than 5000 mg/kg and the no-observed-adverse-effect level (NOAEL) of MEOS for both male and female rats is considered to be 5000 mg/kg per day. R

    In mice, higher dose of Java tea may reduce sperm count and motility along with an sperm mutations. R

    Also in mice, higher dose caused a significant increase in plasma levels of estradiol and decrease in testosterone levels. R

    It may potentiate kidney damage from chemotherapy drugs. R

    Java also inhibits CYP3A4 and CYP2D6 activity. R

    Java may have no effects on weight loss for those who are leptin resistant. R

    Mechanism Of Action

    Simple:

    • Increases Bcl-2 R
    • Increases BMP-2 R
    • Increases Caspase 3/7/8/9 R
    • Increases Collagen type 1 alpha-1 R
    • Increases HDL R
    • Increases Insulin R
    • Increases Leptin R
    • Increases POMC R
    • Increases SOD R
    • Reduces Acetoacetate R
    • Reduces ACE R
    • Reduces alpha-Amylase R
    • Reduces alpha-Glucosidase R R
    • Reduces ALP R
    • Reduces ALT R
    • Reduces AST R
    • Reduces A1R R R
    • Reduces A2AR R
    • Reduces Bax R
    • Reduces Bilirubin R
    • Reduces CYP2D6 R
    • Reduces CYP3A4 R
    • Reduces Glucose R
    • Reduces COX-1 R
    • Reduces COX-2 R R 
    • Reduces IL-1 R
    • Reduces IL-6 R
    • Reduces iNOS R
    • Reduces LDL R
    • Reduces MDA R
    • Reduces NF-kb R
    • Reduces NO R 
    • Reduces NPY R
    • Reduces PGE2 R 
    • Reduces PKA R
    • Reduces STAT1 R
    • Reduces TNF-α (RANKL) R R R
    • Reduces Uric Acid R
    • Reduces VEGF R
    • Reduces 3-HBT R
    • Reduces 5-α reductase R

    Advanced:

    • Java contains β-caryophyllene, caffeic acid, cirrchoric acid, diterpenes, orthosiphols, monoterpenes, triterpenes, saponins, hexoses, organic acids, rosmarinic acids, sinensetin, eupatorin, and 3′-hydroxyl-5,6,7,4′-tetramethoxyflavone. R R R
    • Eupatorin, found in java, has the strongest vasorelaxation effects, which opens up potassium channels and decreases calcium in the cells (muscle). R
    • Eupatorin is also an antagonist of the muscarinic receptor and betaadrenergic receptor. R
    • Eupatorin also arrests cells in the G2/M phase of the cell cycle. R
    • Sinensetin, found in java, produce its ability to inhibit α-glucosidase and α-amylase. R
    • Java reduces appetite probably via increased expression of POMC and decreased expression of NPY in the hypothalamus in association with the elevation of leptin. R

    More Research

    • Extracts of O. stamineus inhibited root and hypocotyl growth of cress (Lepidium sativum) and lettuce (Lactuca sativa) seedlings. R