The 6+ Benefits Of Conessine (With Natural Sources And Mechanisms)

Conessine: The Antibiotic Nootropic


In this post, we will discuss the benefits and natural sources for the steroid alkaloid, Conessine.


  1. Basics Of Conessine
  2. Benefits Of Conessine
  3. My Experience With Conessine
  4. Sources Of Conessine
  5. Caveats
  6. Mechanism Of Action
  7. More Research

Basics Of Conessine

Conessine is a steroid alkaloid found in many species of plants (see sources below). 

Conessine also goes by:

  • Conessin
  • N,N- dimethylcon-5-enin-3-amine
  • Konessin
  • Neriine
  • Roquessine
  • Wrightine

In the brain, it acts as a Histamine H3 Receptor (H3R) Antagonist, which partly regulates its benefits. R

H3R antagonists act differently than other Histamine Receptors (such as H1 and H2). R

Instead of causing down-regulation of histamine in the body, it actually increases the neurotransmitter HistamineR

Benefits Of Conessine

1. May Improve Cognition

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Conessine also easily crosses the Blood-Brain Barrier (BBB). R

Conessine is a H3 antagonist and increases Histamine in the brain, which can increase cognitive function. R

Conessine also increases the neurotransmitter Acetylcholine (ACh) in the brain by reducing the activity of Acetylcholinesterase (AChE). R R

2. Has Antimicrobial Effects


  • Amoeba - Conessine can destruction amoeba without having an emetic effect. R
  • Entamoeba histolytica R 
  • Plasmodium - Conessine is antimalarial R

Conessine may prevent food poisoning. R


  • Acinetobacter baumannii R
  • Bacillus cereus R
  • Bacillus megaterium R
  • Bacillus stearothermophilus R
  • Bacillus subtilis R
  • Pseudomonas aeruginosa R

Conessine can also act synergistically with penicillin and vancomycin (respectively) to have antibiotic effects against Methicillin Sensitive Staphylococcus Aureus (MSSA) and Methicillin Resistant Staphylococcus Aureus (MRSA). R


  • Micrococcus luteus ATCC 9341 R

3. Has Antioxidant Properties

Although weak, conessine does possess some free radical scavenging properties. R

4. Protects The Neurotransmitter Systems From Alcohol Exposure

Conessine can protect the Dopaminergic and Noradrenergic systems of the Prefrontal Cortex (PFC) in the brain from alcohol consumption. R

5. May Improve Muscle Resilience

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Conessine inhibits Autophagy of muscle cells and improves their resilience during oxidative stress. R R

For example, by increasing the expression of MuRF1/Atrogin-1 and reducing FoxO3a/P53, conessine protect against dexamethasone-induced muscle atrophy. R

6. May Reduce Pain

Conessine is a powerful analgesic, but a double-edged sword. R

This is because conessine can reduce pain, but injecting it also causes a great inflammatory response. R

My Experience With Conessine

Conessine improves my focus and libido significantly.

I have to take it in the morning or else it will interfere with sleep.

Sources Of Conessine


These pants in the Apocynaceae family have Conessine:


Do not take while currently experiencing Histamine Intolerance or Mast Cell degranulation. 

Mechanism Of Action


  • Increases ACh R
  • Increases Atrogin-1 R
  • Increases Histamine R
  • Increases MuRF1 R
  • Reduces AChE R
  • Reduces FoxO3a R
  • Reduces H3R R
  • Reduces NF-kB R
  • Reduces P53 R
  • Reduces Trypanothione synthetase R


  • Conessine acts as a histamine antagonist, selective for the H3 subtype (with an affinity of pKi = 8.27; Ki = ~5 nM). R
  • Conessine is much more selective for human H3 versus the H4 receptor (>1860-fold) than the imidazole-based ciproxifan (30-fold selective) and thioperamide (only 1.5-fold selective). R
  • Conessine was also found to exhibit low binding affinity for most other rodent and human G-protein coupled receptors and ligand activated ion channels, with the notable exception of potent affinity for the human alpha2C-adrenergic receptor subtype. R
  • Conessine reduces muscle atrophy by interfering with the expression of atrophy-related ubiquitin ligases MuRF-1 and atrogin-1 and conessine treatment inhibits FoxO3a-dependent transcription, NF-kappaB-dependent transcription and p53-dependent transcription. R
  • Conessine treatment induces the accumulation of enlarged autophagosomes in the cytoplasm by impairing the fusion of autophagosome with a lysosome. R
  • Conessine also inhibits Trypanothione synthetase, which synthesizes trypanothione from glutathione and spermidine. R

More Research

  • Conessine can stop cockroaches from molting. R