The 6+ Benefits Of Conessine (With Natural Sources And Mechanisms)

Conessine: The Antibiotic Nootropic

 
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In this post, we will discuss the benefits and natural sources for the steroid alkaloid, Conessine.

Contents:

  1. Basics Of Conessine
  2. Benefits Of Conessine
  3. My Experience With Conessine
  4. Sources Of Conessine
  5. Caveats
  6. Mechanism Of Action
  7. More Research

Basics Of Conessine

Conessine is a steroid alkaloid found in many species of plants (see sources below). 

Conessine also goes by:

  • Conessin
  • N,N- dimethylcon-5-enin-3-amine
  • Konessin
  • Neriine
  • Roquessine
  • Wrightine

In the brain, it acts as a Histamine H3 Receptor (H3R) Antagonist, which partly regulates its benefits. R

H3R antagonists act differently than other Histamine Receptors (such as H1 and H2). R

Instead of causing down-regulation of histamine in the body, it actually increases the neurotransmitter HistamineR

Benefits Of Conessine

1. May Improve Cognition

 
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Conessine also easily crosses the Blood-Brain Barrier (BBB). R

Conessine is a H3 antagonist and increases Histamine in the brain, which can increase cognitive function. R

Conessine also increases the neurotransmitter Acetylcholine (ACh) in the brain by reducing the activity of Acetylcholinesterase (AChE). R R

2. Has Antimicrobial Effects

Anti-parasitic:

  • Amoeba - Conessine can destruction amoeba without having an emetic effect. R
  • Entamoeba histolytica R 
  • Plasmodium - Conessine is antimalarial R

Conessine may prevent food poisoning. R

Antibacterial:

  • Acinetobacter baumannii R
  • Bacillus cereus R
  • Bacillus megaterium R
  • Bacillus stearothermophilus R
  • Bacillus subtilis R
  • Pseudomonas aeruginosa R

Conessine can also act synergistically with penicillin and vancomycin (respectively) to have antibiotic effects against Methicillin Sensitive Staphylococcus Aureus (MSSA) and Methicillin Resistant Staphylococcus Aureus (MRSA). R

Anti-fungal:

  • Micrococcus luteus ATCC 9341 R

3. Has Antioxidant Properties

Although weak, conessine does possess some free radical scavenging properties. R

4. Protects The Neurotransmitter Systems From Alcohol Exposure

Conessine can protect the Dopaminergic and Noradrenergic systems of the Prefrontal Cortex (PFC) in the brain from alcohol consumption. R

5. May Improve Muscle Resilience

 
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Conessine inhibits Autophagy of muscle cells and improves their resilience during oxidative stress. R R

For example, by increasing the expression of MuRF1/Atrogin-1 and reducing FoxO3a/P53, conessine protect against dexamethasone-induced muscle atrophy. R

6. May Reduce Pain

Conessine is a powerful analgesic, but a double-edged sword. R

This is because conessine can reduce pain, but injecting it also causes a great inflammatory response. R

My Experience With Conessine

Conessine improves my focus and libido significantly.

I have to take it in the morning or else it will interfere with sleep.

Sources Of Conessine

 
 

These pants in the Apocynaceae family have Conessine:

Caveats

Do not take while currently experiencing Histamine Intolerance or Mast Cell degranulation. 

Mechanism Of Action

Simple:

  • Increases ACh R
  • Increases Atrogin-1 R
  • Increases Histamine R
  • Increases MuRF1 R
  • Reduces AChE R
  • Reduces FoxO3a R
  • Reduces H3R R
  • Reduces NF-kB R
  • Reduces P53 R
  • Reduces Trypanothione synthetase R

Advanced:

  • Conessine acts as a histamine antagonist, selective for the H3 subtype (with an affinity of pKi = 8.27; Ki = ~5 nM). R
  • Conessine is much more selective for human H3 versus the H4 receptor (>1860-fold) than the imidazole-based ciproxifan (30-fold selective) and thioperamide (only 1.5-fold selective). R
  • Conessine was also found to exhibit low binding affinity for most other rodent and human G-protein coupled receptors and ligand activated ion channels, with the notable exception of potent affinity for the human alpha2C-adrenergic receptor subtype. R
  • Conessine reduces muscle atrophy by interfering with the expression of atrophy-related ubiquitin ligases MuRF-1 and atrogin-1 and conessine treatment inhibits FoxO3a-dependent transcription, NF-kappaB-dependent transcription and p53-dependent transcription. R
  • Conessine treatment induces the accumulation of enlarged autophagosomes in the cytoplasm by impairing the fusion of autophagosome with a lysosome. R
  • Conessine also inhibits Trypanothione synthetase, which synthesizes trypanothione from glutathione and spermidine. R

More Research

  • Conessine can stop cockroaches from molting. R