The 12+ Benefits of Wrightia Tinctoria (Indrajauis, Shwetha Kutaja, Pala Indigo)

Wrightia Tinctoria: Improve Wound Healing, Kill Microbes

 
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Wrightia tinctoria is medicinal plant that can improve skin quality and prevent metabolic disease.

In this post, we will discuss its benefits, how to use it, and it's medicinal mechanism.

Contents:

  1. Basics
  2. Benefits Of Wrightia Tinctoria
  3. My Experience With Wrightia Tinctoria
  4. Where To Buy Wrightia Tinctoria
  5. Caveats
  6. Components Of Wrightia
  7. Mechanism Of Action
  8. More Research

Basics

Wrightia tinctoria (male form of Kutaja) is also called Shwetha Kutaja, Pala Indigo, Dyers’s Oleander, and Indrajauis.

In Ayurvedic medicine: R

  • Seeds - used as anthelmintic, antidiarrhoeal, antidysenteric, astringent, febrifuge, seminal weakness and as an aphrodisiac.
  • Leaves/bark (decoction) - used for fever febrifuge, toothache, stomach/bowel complaints
  • Bark - used as an antidysenteric and treat skin diseases and biliousness

The major bioactive triterpenes of Wrightia are α-amyrin, β amyrin, lupeol, and β-sitosterol (see more in Components Of Wrightia). R

 
 

Benefits Of Wrightia Tinctoria

1. Ameliorates Psoriasis

In clinical studies, Wrightia has shown to improve Psoriasis. R

It has strong Antipsoriatic activity and is used for Psoriasis treatment (reduces lesions, pain, and itching). R R

2. May Help Cancer Treatment

Wrightia has anti-canter activity on:

  • Breast Cancer R R
  • Cervical Cancer R
  • Leukemia R
  • Liver Cancer R
  • Melanoma R

3. Improves Wound Healing

 
 http://www.mdpi.com/1422-0067/17/2/160/htm

http://www.mdpi.com/1422-0067/17/2/160/htm

 

Wrightia is powerful at wound healingR R

It improves breaking strength of the skin and improves wound closure/epithelialisation time. R

In the form of latex cream, Wrightia enhances wound healing by improving collagen synthesis and matrix metalloproteinase (MMP) activity. R

4. Combats Obesity, Cholesterol, And Protects The Vascular System

Wrightia may protect against dyslipidemia and weight gain from a high fat diet. R

Chlorogenic acid (found in Wrightia) can protect against high cholesterol buildup (inhibits platelet aggregation). R

For example, in animal models eating a high fat diet, Wrightia decreased serum total cholesterol (TC) and low-density lipoprotein (LDL), improved high-density lipoprotein (HDL), and prevented weight gain. R

Wrightia can lower high Blood PressureR

5. Fights Diabetes

Wrightia has powerful anti-diabetic properties. R R

The chloroform extract of Wrightia has significant anti-diabetic activity compared to the standard drug glibenclamide. R

In animal models of diabetes, wrightia can reduce blood glucose levels. R R

6. Has Antimicrobial Effects

Wrightia has antibacterial activity against:

  • Bacillus cereus (incl MTCC 1305) R R
  • Bacillus licheniformis R
  • Bacillus subtilis (incl MTCC 2423) R R R
  • Escherichia coli (incl MTCC 443) R R R R
  • Klebsiella pneumonia R
  • Micrococcus luteus (incl MTCC 1541) R
  • Morexalla catarrhalis R
  • Proteus vulgaris (incl MTCC 1771) R
  • Pseudomonas aeruginosa (incl MTCC 424) R R
  • Salmonella paratyphi (incl MTCC 735) R
  • Salmonella typhi (incl MTCC 98) R
  • Staphylococcus aureus (incl ATCC 25923 and MTCC 96) R R R
  • Staphylococcus citreus R
  • Staphylococcus epidermidis (incl MTCC 2639) R
  • Streptococcus pneumoniae R
  • Streptococcus sanguinis R

Wrightia has antifungal activity against:

  • Acaulospora delicata R
  • Acaulospora nicolson R
  • Aspergillus flavus (incl MTCC-1783)  R
  • Aspergillus niger (incl MTCC 1344) R
  • Candida albicans (incl MTCC 227) R R R
  • Candida parapsilosis R
  • Cryptococcus R
  • Epidermophyton floccosum (incl MTCC 7880) R
  • Glomus aggregatum R
  • Glomus mosseae R
  • Microsporum canis (incl MTCC 2820) R
  • Pityrosporum ovale R
  • Sclerocystis microcarpus R
  • Scopulariopsis brevicaulis R
  • Trichophyton mentographytes (incl MTCC 7687) R
  • Trichophyton rubrum (incl MTCC 3272) R R
  • Trichophyton simii R
  • Trichophyton tonsurans R

Wrightia has antiviral activity against:

  • Hepatitis C R
  • Herpes R
  • HIV-1 (IIIB) R
  • H1N1 R

Wrightia has anthelmintic activity aginst:

  • Pheritima posthum R

7. Has Antioxidant Properties

Wrightia has strong antioxidant properties. R

Wrightia is rich in natural antioxidants (e.g. phenols and flavonoids). R 

Wrightia has stronger free radical scavenging properties than Vitamin C and Rutin. R

8. May Act As A Contraceptive

 
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As wrightia tinctoria has Pro-Estrogenic effects, it has shown to useful as a Contraceptive. R

9. Protects The Liver

The triterpenoids in Wrightia tinctoria are well reported to have hepatoprotective activity. R

Lupeol and β-amyrin (triterpenoids from Wrightia tinctoria) can improve Glutathione (GSH) and (Superoxide Dismutase (SOD) levels in the liver, thus protecting against Carbon Tetrachloride (CCL4)-induced acute liver toxicity. R

In the same animal model study, lupeol, b-amyrin, and b-sitosterol were able to prevent SGPT, SGOT and ALP increase from CCL4 liver toxicity. R

10. Protects Gut From Ulcers

Wrightia leaves possesses anti-ulcer effects. R

Methanolic extracts have shown significant gastro-protective activity (of 65.89%) when compared with the standard drug famotidine (which showed 75.34%). R 

11. Improves Pain

 
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Wrightia has analgesic effects. R

12. Enhances Libido

 Laddus made of baked Wrightia seeds has been described as a remedy for improving libido. R

My Experience With Wrightia Tinctoria

I've used Wrightia Oinment on scabs and I've noticed less scarring on the areas I've used it.

Where To Buy Wrightia Tinctoria

 
 

There are a few topical forms:

It can also be taken orally as Bark or Seeds.

Caveats

Wrightia may smell/taste awful. R

Do not take while pregnant as it may terminate pregnancy. R

Supplementation of wrightia is mostly safe -  using a very high oral dose of 2500 mg/kg crude extract showed no mortalities or adverse effects in mice. R

Wrightia tinctoria extract considerably increases urine volume, acting as strong kaliuretic. R

Components Of Wrightia

Phytoconstituents present in the plant include glycosides, steroids, triterpenoids, saponins, tannins, phenolics, and flavonoids. R

Leaves: R

  • Triacontanol
  • Tryptanthrin

Mature Powdered Pods: R

  • β-amyrin
  • Ursolic acid
  • Oleanolic acid
  • β-sitosterol

Menthol Extract: R R

  • Cycloartenone
  • β-amyrin
  • cycloeucalenol
  • β-sitosterol
  • Wrightial (a new terpene)
  • Gallic acid
  • Rutin
  • Quercetin
  • Indirubin (strong anti-fungal) R

Seeds: R

  • 14 α-methylzymosterol (A new sterol)
  • Desmosterol
  • Clerosterol
  • 24-methylene-25-methylcholesterol
  • 24-dehydropollinastanol

Stem Bark: R

  • β-amyrin
  • Lupeol
  • β-sitosterol

Other:

  • Other extracts also include Tannins, Alkaloids Flavonoids, Phenols, Saponins, Sterols, Quinones, Carbohydrates, and Terpenoids R

Mechanism Of Action

Simple:

  • Increases GLUT4 R
  • Increases GSH R
  • Increases HDL R
  • Increases SOD R
  • Reduces Akt R
  • Reduces ALP R
  • Reduces Bcl-2 R
  • Reduces BRAF R
  • Reduces Brn-2 R
  • Reduces β-catenin R
  • Reduces COX-2 R
  • Reduces ERK1/2 R
  • Reduces Glucose R R
  • Reduces LDL R
  • Reduces MMP-9 R
  • Reduces NF-kB R
  • Reduces SGOT R
  • Reduces SGPT R
  • Reduces TC R
  • Reduces VEGF R
  • Reduces WNT R

Advanced:

  • Increase in glutathione activity indicated that WTTF helps in the restoration of vital molecules such as NAD, cytochrome and glutathione. R
  • The active ethanolic extract and its fractions exhibited moderate to potent estrogen-agonistic activity, which might be responsible for their contraceptive action in this species. R
  • Wt.Cr(++) lowers blood pressure through a combination of K(+)-channel opening and Ca(++)-channel blocking effects along with antidyslipidemic and weight-reducing properties. R
  • There are 67 compounds in Wrightia with 238 potential protein/gene targets. R

More Research

  • Indigoid Dyes from pala indigo (Wrightia tinctoria) can be used as coloring matter. R
  • Its stem bark extract is used in animals for the treatment of Anthrax. R