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CancerWhat Is A Peptidein? Inside The Dark Proteome Discovery Reshaping Human Biology
Scientists just confirmed a new class of small protein-like molecules, called peptideins, hiding in DNA long assumed to code for nothing. Here is what they are, why they are not the peptide therapies…
CancerDiscoidin Domain Receptors (DDR1 and DDR2): Activators And Inhibitors
DDR1 and DDR2 are tyrosine kinase receptors in the extracellular matrix that mediate mediate cell aggregation.
BrainSabroxy (Oroxylum Indicum): How The Bark Extract Works On Dopamine, BDNF, And Aging Memory
Sabroxy is a standardized Oroxylum indicum bark extract marketed as a natural methylphenidate candidate, and the evidence on it runs from an 82-person randomized trial to an eight-fold BDNF signal in…
SupplementsDr. Nathan Bryan - All About Nitric Oxide In The Body and Chronic Disease
Dr. Nathan Bryan and I discuss a common underlying problem in most chronic illness - dysregulation of nitric oxide.
Infections191+ Ways To Combat Herpes (Inhibit HSV1 and HSV2)
Herpes is one of the most common sexually transmitted diseases which can affect multiple organ systems including the lips and genitals.In this post, we will discuss herpes (HSV-1 and HSV-2), how it…
DrugsAminophenazone (Aminopyrine): The Analgesic That Was Pulled From Markets Worldwide
Aminophenazone was one of the most widely used analgesics in the first half of the twentieth century. It is now banned or withdrawn in most developed nations due to immune-mediated agranulocytosis…
SkinThe Neuroscience Of Itch: Why You Itch, Why Antihistamines Fail, And How To Break The Scratch Cycle
Most chronic itch is not histamine-driven, which is why antihistamines fail for it, and the dorsal horn runs itch through its own dedicated GRPR relay rather than sharing the pain pathway. Here is…
DrugsPT-141 (Bremelanotide): The First Centrally Acting Drug For Sexual Desire
PT-141 (bremelanotide) is a synthetic cyclic peptide that acts on melanocortin receptors in the brain to drive sexual desire and arousal. This post covers the melanocortin system, Phase 3 clinical…
SupplementsWhy Your Bones Rely On Preptin
Preptin improves bone structure and regulates metabolism.It can predict many diseases and helps regulate blood sugar, the skeletal system, and blood pressure.
Oxidative stress8-OHdG: The DNA Damage Biomarker That Tells You How Fast You Are Aging At The Cellular Level
8-OHdG is the most widely studied oxidative DNA damage biomarker in human medicine. Every cell in your body produces oxidative damage to its own DNA every day, and the rate at which that damage…
ExerciseThe Ventromedial Hypothalamus: How A Tiny Brain Region Stores Your Exercise History And Drives Endurance
The ventromedial hypothalamus is a small brain nucleus that controls metabolic rate, glucose handling, fear, aggression, and now appears to store a physical memory of past exercise through SF1 neuron…
SupplementsTaurine: The Conditionally Essential Amino Acid and the Deficiency-of-Aging Hypothesis
Taurine is the most abundant free amino acid in your heart, muscle, and retina, yet it builds no protein. Here is what the evidence actually shows on aging, blood pressure, mitochondria, bile, and…
SupplementsPMDD: The Neurobiology Behind Premenstrual Dysphoric Disorder And How To Address It
Premenstrual dysphoric disorder (PMDD) is a severe cyclic mood disorder with a distinct neurobiological basis involving allopregnanolone, GABA receptor sensitivity, serotonin, and a frequently…
MindsetHow To Control Your Reticular Activating System
I've always believed in "what you focus on grows... where focus goes, energy flows". - Tony RobbinsThe Reticular Activating System (RAS) provides the major pathology for being in the "flow state".
ProbioticsThe Gut-Skin Axis: How Postbiotics And SCFAs Reach The Follicle
The gut-skin axis is the bidirectional signaling network linking the gut microbiome to inflammatory skin disease. This post covers how short-chain fatty acids, Tregs, and tryptophan-derived AhR…
Mitochondria TrendingNAD+, NADH, NADP+, And NADPH: The Redox Molecules Running Every Cell You Have
These four molecules are the reason your cells can make energy, repair DNA, neutralize free radicals, synthesize fat, and stay alive. NAD+/NADH operates in catabolic metabolism, while NADP+/NADPH…
DrugsKeeping Muscle On GLP-1 Drugs: Semaglutide, Tirzepatide, And Retatrutide
GLP-1 drugs like semaglutide, tirzepatide, and retatrutide strip fat fast, but roughly a quarter to a third of the weight lost is lean mass, the part you cannot afford to lose. Here is what the trial…
SupplementsMyBioHack Podcast Episode #1 - Burdock Root
MyBioHack Podcast Episode #1 - Burdock RootMy full review can be seen here - https://mybiohack.com/blog/burdock-arctium-lappa-arctigenin-arctiin