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POTSThe Hypermobility-MCAS-POTS Triad: Why hEDS, Mast Cells, and Dysautonomia Travel Together
hEDS, MCAS, and POTS cluster in the same patients far more than chance, and in my model the shared root is not collagen alone but the glycocalyx and the small vessels it protects. In this post I work…
DrugsGLP-1 And The GLP-1 Receptor: How The Hormone Works, What The Drugs Actually Do, And How To Support It Naturally
GLP-1 is an incretin hormone that regulates blood glucose, appetite, and gastric emptying through a class B GPCR signaling cascade. This post covers GLP-1 biology from synthesis to degradation, the…
NootropicsThe 6+ Benefits Of Conessine (With Natural Sources And Mechanisms)
In this post, we will discuss the benefits and natural sources for the steroid alkaloid, Conessine.
MCASMast Cells, Substance P, And Neurogenic Inflammation: The Nerve-To-Mast-Cell Loop Behind Flushing And MCAS
Your own nerves can fire mast cells with no allergy involved. Here is the substance P and MRGPRX2 loop behind flushing, hives, and MCAS.
ProbioticsAll The Different Strains Of Lactobacillus: A Complete Guide To The Species That Used To Be One Genus
Lactobacillus used to be one genus that covered everything from vaginal flora to sauerkraut bacteria, and in 2020 it was formally split into 25 genera. In this post, we discuss what Lactobacilli are,…
SupplementsThe 7+ Benefits of Rubiscolins (Opioid Peptide From Rubisco)
Rubiscolins are naturally occurring opioid peptides that come from Spinach.In this post, we will discuss the benefits of Rubsicolin (-5 and -6) and their mechanism of action.
HormonalEstrogen Receptors, Estrogenics, And The Rise of Western Disease (Part 1)
In this post we are going to be discussing estrogen receptors and how estrogen affects the body.
EpigeneticsEpigenetic Clocks And Biological Age: What DNA Methylation Testing Can And Cannot Tell You
Epigenetic clocks estimate biological age from DNA methylation, but the single number most people buy is easy to misread. Here is what biological age actually means, how the three generations of…
SupplementsBirth Control and Hormonal Contraceptive Alternatives With Important Supplements
This post will recap some of the problems with modern birth control on the body and give some more natural alternatives.
SleepThe Gut Microbiome And Insomnia: How Dysbiosis Disrupts Sleep
A 2026 severity-graded sequencing study found the gut microbiome shifts in direct proportion to insomnia severity, with SCFA-producing Clostridia collapsing as sleep worsens. This breaks down the…
DysautonomiaVestibular Migraine and Chronic Vertigo: The Dysautonomia Connection
Vestibular migraine is the most common cause of recurrent spontaneous vertigo, driven by a trigeminovascular and mast cell loop that overlaps heavily with POTS and hypermobility. This post covers the…
DrugsKeeping Muscle On GLP-1 Drugs: Semaglutide, Tirzepatide, And Retatrutide
GLP-1 drugs like semaglutide, tirzepatide, and retatrutide strip fat fast, but roughly a quarter to a third of the weight lost is lean mass, the part you cannot afford to lose. Here is what the trial…
SupplementsThe 14+ Benefits Of Kutaj & Kwatha (Holarrhena antidysenterica)
In this post, we will discuss the Ayurvedic herb, Kutaja, its many benefits, mechanism, and what to watch out for.
VascularLymphatic System Support: How To Improve Lymph Flow And Drainage
The lymphatic system is a blind-ended, unidirectional network that depends on mechanical forces rather than a central pump, making it uniquely vulnerable to stagnation in chronic illness. In this…
ThyroidAshwagandha (Withania somnifera): Benefits, Mechanisms, And What The Adaptogen Evidence Actually Shows
Ashwagandha is the most heavily studied adaptogen on the market, with strong RCT support for lowering cortisol but a much weaker case for testosterone. This post covers the withanolide mechanisms,…
SupplementsWhy Your Bones Rely On Preptin
Preptin improves bone structure and regulates metabolism.It can predict many diseases and helps regulate blood sugar, the skeletal system, and blood pressure.
CancerOpposites Attract: Cancer and Alzheimer's Disease
Cancer and Alzheimer's are inversely correlated.Biomarkers in cancer and Alzheimer's seem to be opposites. Let's delve into why.
DietThe Best Ways to Regulate Menopause
Menopause, also known as the climacteric, is the time in most women's lives when menstrual periods stop permanently, and they are no longer able to bear children. Menopause (climacteric) typically…